Clinical challenge for gastroenterologists–Gastrointestinal manifestations of systemic mastocytosis: A comprehensive review

Table 2 B and C Findings in systemic mastocytosis

B and C Findings in systemic mastocytosis
B Findings
BM biopsy showing > 30% infiltration by MCs (focal, dense aggregates) and serum total tryptase level > 200 ng/mL
Myeloproliferation or signs of dysplasia in non-MC lineage(s), no prominent cytopenias; criteria for AHN not met
Hepatomegaly and/or splenomegaly on palpation without impairment of organ function and/or lymphadenopathy on palpation/imaging (> 2 cm)
C Findings1
Cytopenia(s): ANC < 1 × 109/L, Hb < 10 g/dL, or platelets < 100 × 109/L
Hepatomegaly on palpation with impairment of liver function, ascites, and/or portal hypertension
Skeletal lesions: Osteolyses and/or pathologic fractures
Palpable splenomegaly with hypersplenism
Malabsorption with weight loss from gastrointestinal tract MC infiltrates

¹Must be attributable to the mast cell infiltrate. AHN: Associated hematological neoplasm; ANC: Absolute neutrophilic count; BM: Bone marrow; MCs: Mast cells.