Combination approaches in hepatocellular carcinoma: How systemic treatment can benefit candidates to locoregional modalities

doi:10.3748/wjg.v28.i28.3573

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Jul 28, 2022 (publication date) through Nov 4, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 28, 2022; 28(28): 3573-3585
Published online Jul 28, 2022. doi: 10.3748/wjg.v28.i28.3573

Table 3 Clinical trials approaching combination of systemic treatment and intra-arterial actually enrolling, recruiting or waiting for final results

Trial	Trial registration	Drug	Control	n	Disease stage	Local treatment	Expected termination	Primary end-point
EMERALD-1	NCT03778957	Durvalumab + Bevacizumab plus TACE	TACE plusplacebo	600	Intermediate/advanced	TACE	2024	Progression-free survival
TACE-3	NCT04268888	Nivolumab plus DEB- TACE	DEB- TACE	522	Intermediate	DEB-TACE	2026	Overall survival
LEAP-012	NCT04246177	Lenvatinib plus Pembrolizumab plus cTACE	cTACE	950	Intermediate	Surgery/Ablation	2029	Overall survival and progression-free survival
CheckMate 74 W	NCT04340193	Nivolumab plusIpilimumab/placebo plus cTACE	cTACE plusplacebo	765	Intermediate	Surgery/Ablation	Non-available	Time-to-progression and overall survival

c: Conventional; DEB: Drug-eluting beads; TACE: Transarterial chemoembolization.

Citation: da Fonseca LG, Araujo RLC. Combination approaches in hepatocellular carcinoma: How systemic treatment can benefit candidates to locoregional modalities. World J Gastroenterol 2022; 28(28): 3573-3585
URL: https://www.wjgnet.com/1007-9327/full/v28/i28/3573.htm
DOI: https://dx.doi.org/10.3748/wjg.v28.i28.3573