Combination approaches in hepatocellular carcinoma: How systemic treatment can benefit candidates to locoregional modalities

Table 1 Clinical trials in advanced hepatocellular carcinoma with combination of systemic treatment

Study name	Design	Experimental arm	Median overall survival, mo	Response rate- RECIST, %	Grade 3 - 4 treatment-related adverse events
IMBRAVE 150[21]	Phase III; First-line	Atezolizumab + Bevacizumab	19.2	30%	36%
KEYNOTE 524/Study 116[22]	Phase Ib; First-line	Pembrolizumab + Lenvatinib	22	36%	67%
REG-PEMBRO-HCC[23]	Phase Ib; First-line	Pembrolizumab + Regorafenib	26.5	32%	86%
CHECKMATE 040[24]	Phase II; Second-line	Nivolumab + Ipilimumab (arm A)	22.8	32%	53%
STUDY 22[27]	Phase II; Second-line	Durvalumab + Tremelimumab	18.7	24%	35.1%
CHECKMATE-040[25]	Phase II; First and second-line	Nivolumab + Ipilimumab + Cabozantinib	Not-reached	26%	71%