Interventional strategies in infected necrotizing pancreatitis: Indications, timing, and outcomes

Figure 1 Mortality rates of acute pancreatitis and pathomechanisms. The mortality rate of all patients with acute pancreatitis (AP) is less than 10%. One-fifth of the patients developed necrotizing AP by ATP depletion, MLKL phosphorylation, acinar cell necroptosis, and/or acinar cell necrosis. One-third of the patients with necrotizing AP developed bacterial or fungal infection. The mortality rate of the infected necrotizing pancreatitis is up to 39%.