Novel index for the prediction of significant liver fibrosis and cirrhosis in chronic hepatitis B patients in China

Table 2 Univariate analysis in the training cohort

Parameter	Fibrosis (F0-1) (n = 113)1	Fibrosis (F2-4) (n = 183)1	P value
Age (yr)	45.15 ± 14.97	43.63 ± 13.32	0.363
Gender: Female/male (n)	37/76	38/145	0.021
WBC (× 109/L)	6.45 ± 3.02	5.55 ± 2.14	0.003
NEUT (× 109/L)	4.14 ± 3.0	3.18 ± 1.95	0.001
LYMPH (× 109/L)	1.67 ± 0.60	1.68 ± 0.63	0.828
PLT (× 109/L)	206.0 ± 68.39	150.55 ± 56.49	< 0.001
Albumin (g/L)	41.26 ± 5.93	39.29 ± 5.66	0.005
Globulin (g/L)	27.46 ± 4.46	31.04 ± 5.56	< 0.001
TBIL (μmol/L)	13.82 ± 7.06	17.12 ± 8.8	< 0.001
DBIL (μmol/L)	6.43 ± 3.72	7.81 ± 4.49	< 0.001
ALT (U/L)	65.01 ± 70.72	78.42 ± 66.62	0.101
AST (U/L)	56.61 ± 55.11	82.45 ± 66.09	0.001
ALP (U/L)	79.06 ± 34.16	109.2 ± 42.31	< 0.001
γ-GT (U/L)	51.84 ± 47.06	106.5 ± 73.21	< 0.001
AGPR	0.72 ± 0.49	1.61 ± 0.83	< 0.001

¹Data presented as the mean ± SD or proportions.

WBC: White blood cell; NEUT: Neutrophil count; LYMPH: Lymphocyte count; PLT: Platelet; TBIL: Total bilirubin; DBIL: Direct bilirubin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALP: Alkaline phosphatase; γ-GT: Gamma-glutamyl transpeptidase; AGPR: [Alkaline phosphatase (U/L) + gamma-glutamyl transpeptidase (U/L)]/platelet (10⁹/L).