Novel index for the prediction of significant liver fibrosis and cirrhosis in chronic hepatitis B patients in China

Table 1 Clinical and biochemical data of examined patients

Parameter	Training cohort (n = 296)1	Validation cohort (n = 211)1	P value
Age (yr)	42.47 ± 11.98	41.21 ± 11.36	0.167
Gender: Female/male (n)	75/221	40/171	0.091
Drinking: Yes/no (n)	127/169	101/110	0.268
Smoking: Yes/no (n)	92/204	68/143	0.784
HbeAg: Negative/positive	16/280	15/196	0.430
Fibrosis stage: F0/F1/F2/F3/F4	55/58/75/64/44	47/47/37/54/26	0.194
Activity grade: A0/A1/A2/A3/A4	16/92/113/69/6	15/72/69/52/3	0.446
WBC (× 109/L)	5.89 ± 2.55	6.34 ± 4.32	0.150
NEUT × 109/L)	3.55 ± 2.44	3.66 ± 2.61	0.611
LYMPH (× 109/L)	1.72 ± 0.62	1.80 ± 0.63	0.063
PLT (× 109/L)	171.61 ± 66.87	174.48 ± 61.62	0.636
Albumin (g/L)	41.12 ± 19.09	39.94 ± 6.07	0.380
Globulin (g/L)	29.67 ± 5.45	29.14 ± 5.80	0.298
TBIL (μmol/L)	16.51 ± 8.44	16.73 ± 7.63	0.768
DBIL (μmol/L)	6.91 ± 5.03	7.07 ± 4.33	0.699
ALT (U/L)	73.31 ± 65.41	96.85 ± 83.62	0.002
AST (U/L)	72.59 ± 63.29	77.44 ± 67.34	0.411
ALP (U/L)	97.70 ± 41.98	104.32 ± 49.25	0.104
γ-GT (U/L)	85.64 ± 69.68	97.98 ± 75.36	0.058
AGPR	1.26 ± 0.84	1.32 ± 0.89	0.431

¹Data presented as the mean ± SD or proportions.

HbeAg: Hepatitis B e-antigen; WBC: White blood cell; NEUT: Neutrophil count; LYMPH: Lymphocyte count; PLT: Platelet; TBIL: Total bilirubin; DBIL: Direct bilirubin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALP: Alkaline phosphatase; γ-GT: Gamma-glutamyl transpeptidase; AGPR: [Alkaline phosphatase (U/L) + gamma-glutamyl transpeptidase (U/L)]/platelet (10⁹/L).