Prognostic significance of hemoglobin, albumin, lymphocyte, platelet in gastrointestinal stromal tumors: A propensity matched retrospective cohort study

doi:10.3748/wjg.v28.i27.3476

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World Journal of Gastroenterology

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Retrospective Cohort Study

World J Gastroenterol. Jul 21, 2022; 28(27): 3476-3487
Published online Jul 21, 2022. doi: 10.3748/wjg.v28.i27.3476

Table 2 Univariate and multivariate regression analysis of prognostic factors in patients before and after propensity scores matching

Risk factors	Before PSM				After PSM
Risk factors	Univariate analysis, HR (95%CI)	Univariate analysis, P value	Multivariate analysis, HR (95%CI)	Multivariate analysis, P value	Univariate analysis, HR (95%CI)	Univariate analysis, P value	Multivariate analysis, HR (95%CI)	Multivariate analysis, P value
Age	1.009 (0.987-1.030)	0.431		NS	1.006 (0.984-1.027)	0.607		NS
Sex: Male vs female	0.639 (0.386-1.056)	0.081		NS	0.711 (0.429-1.179)	0.186		NS
Tumor site: Stomach vs non-stomach	2.273 (1.377-3.752)	0.001^a	2.979 (1.716-5.171)	< 0.001^a	1.702 (1.028-2.818)	0.039^a	2.865 (1.631-5.032)	< 0.001^a
Tumor size in cm: ≤ 2/2.1-5.0/5.1-10.0/> 10.0	2.629 (1.948-3.548)	< 0.001^a	1.070 (1.032-1.109)	0.001^a	1.086 (1.056-1.116)	< 0.001^a	1.068 (1.029-1.107)	< 0.001^a
Mitotic index as/50 HPF: ≤ 5/6-10/> 10/unknown	2.071 (1.686-2.545)	< 0.001^a		< 0.001^a		< 0.001^a		0.001^a
≤ 5 vs 6-10			5.659 (2.151-14.887)	0.002^a	5.442 (2.067-14.323)	0.001^a	5.444 (1.955-15.162)	0.001^a
≤ 5 vs > 10			8.259 (3.140-21.720)	< 0.001^a	14.722 (6.037-35.904)	< 0.001^a	7.675 (2.759-21.348)	< 0.001^a
≤ 5 vs unknown			5.299 (2.041-13.757)	< 0.001^a	9.851 (3.843-25.251)	< 0.001^a	5.107 (1.873-13.923)	0.001^a
CD117: +/-	1.231 (0.300-5.059)	0.773		NA	1.291 (0.314-5.313)	0.723	-	NA
DOG1: +/-/unknown	1.464 (0.773-2.774)	0.242		NA	1.626 (0.853-3.102)	0.140	-	NA
Ki67: ≤ 10/> 10/unknown	1.919 (1.453-2.533)	< 0.001^a		0.001^a		< 0.001^a		0.001^a
< 10 vs ≤ 10			3.579 (1.771-7.233)	< 0.001^a	8.625 (4.750-15.660)	< 0.001^a	3.710 (1.811-7.599)	< 0.001^a
Unknown vs ≤ 10			2.844 (1.290-6.270)	0.024^a	3.310 (1.528-7.169)	0.002^a	3.050 (1.365-6.816)	0.007
Histologic subtypes: Spindle/epithelioid/mixed	1.361 (0.981-1.889)	0.065		NS	1.236 (0.891-1.715)	0.204	-	NA
NIH risk category: Very low/low/intermediate/high	3.218 (2.180-4.751)	< 0.001^a		NS	2.892 (1.865-4.484)	< 0.001^a	-	NS
Adjuvant therapy: Yes/no	1.289 (0.768-2.162)	0.336	0.445 (0.257-0.769)	0.004^a	0.923 (0.549-1.551)	0.761		0.003^a
NLR: < 2.60/≥ 2.60	2.025 (1.229-3.337)	0.006^a		NS	1.746 (1.055-2.890)	0.030^a		NS
PLR: < 134.8/≥ 134.8	2.925 (1.673-5.112)	< 0.001^a		NS	1.991 (1.137-3.486)	0.016^a		NS
LMR: < 4.0/≥ 4.0	1.296 (0.777-2.163)	0.321		NA	1.088 (0.650-1.821)	0.749	-	NA
PNI: < 48.6/≥ 48.6	0.291 (0.171-0.496)	< 0.001^a		NS	1.991 (1.137-3.486)	0.016^a		NS
HALP: < 31.5/≥ 31.5	0.341 (0.197-0.590)	< 0.001^a	0.506 (0.291-0.879)	0.016^a	0.457 (0.265-0.785)	0.005^a	0.558 (0.319-0.976)	0.041^a

^aP < 0.05 was considered statistically significant.

CI: Confidence interval; HALP: Combination index of hemoglobin, albumin, lymphocyte, and platelet; HPF: High-power field; HR: Hazard ratio; NA: Not adopted; LMR: Lymphocyte-to-monocyte ratio; NIH: National Institutes of Health; NLR: Neutrophil-to-lymphocyte ratio; NS: Not significant; PLR: Platelet-to-lymphocyte ratio; PNI: Prognostic nutritional index; PSM: Propensity scores matching.

Citation: Zhao Z, Yin XN, Wang J, Chen X, Cai ZL, Zhang B. Prognostic significance of hemoglobin, albumin, lymphocyte, platelet in gastrointestinal stromal tumors: A propensity matched retrospective cohort study. World J Gastroenterol 2022; 28(27): 3476-3487
URL: https://www.wjgnet.com/1007-9327/full/v28/i27/3476.htm
DOI: https://dx.doi.org/10.3748/wjg.v28.i27.3476