Prognostic significance of hemoglobin, albumin, lymphocyte, platelet in gastrointestinal stromal tumors: A propensity matched retrospective cohort study

Table 1 Baseline characteristics in patients with high or low combination index of hemoglobin, albumin, lymphocyte, and platelet before and after propensity scores matching (mean ± SD)

Characteristics	Before PSM1				After PSM
	All	Low HALP, < 31.5	High HALP, ≥ 31.5	P value	All	Low HALP, < 31.5	High HALP, ≥ 31.5	P value
n (%)	591	229 (38.7)	362 (61.3)	-	458	229 (50)	229 (50)	-
Age in yr	56.3 ± 12.0	56.7 ± 12.2	56.1 ± 11.8		56.8 ± 12.1	56.7 ± 12.2	57.0 ± 12.1
< 60	337 (57.0)	129	208		256 (55.9)	129	127
≥ 60	254 (43.0)	100	154	0.788	202 (44.1)	100	102	0.851
Sex
Male	280 (47.4)	98	182		233 (50.9)	131	102
Female	311 (52.6)	131	180	0.076	225 (49.1)	98	127	0.007a
Tumor site
Stomach	424 (71.7)	143	281		299 (65.3)	143	156
Non-stomach	167 (28.3)	86	81	< 0.001a	159 (34.7)	86	73	0.202
Tumor size in cm	6.16 ± 4.87	7.69 ± 5.65	5.18 ± 4.02		7.13 ± 5.08	7.69 ± 5.65	6.57 ± 4.38
≤ 2	86 (14.6)	10	76		27 (5.9)	10	17
2.1-5.0	251 (42.5)	87	164		177 (38.6)	87	90
5.1-10.0	184 (31.1)	95	89		184 (40.2)	95	89
> 10.0	70 (11.8)	37	33	< 0.001a	70 (15.3)	37	33	0.514
Mitotic index/50 HPF
≤ 5	332 (56.2)	107	225		220 (48.0)	107	113
6-10	100 (16.9)	45	55		91 (19.9)	45	46
> 10	91 (15.4)	49	42		89 (19.4)	49	40
Unknown	68 (11.5)	28	40	0.001a	58 (12.7)	28	30	0.764
Ki67
≤ 10	417 (70.6)	140	277		308 (67.3)	140	168
> 10	98 (16.6)	61	37		94 (20.5)	61	33
Unknown	76 (12.9)	28	48	< 0.001a	26 (12.2)	28	28	0.004a
NIH risk category
Very low risk	72 (12.2)	9	63		21 (4.6)	9	12
Low risk	178 (30.1)	52	126		113 (24.7)	52	61
Intermediate risk	114 (19.3)	43	71		100 (21.8)	43	57
High risk	227 (38.4)	125	102	< 0.001a	224 (48.9)	125	99	0.106
Adjuvant therapy
Yes	201 (34.0)	99	102		193 (42.1)	99	94
No	390 (66.0)	130	260	< 0.001a	265 (57.9)	130	135	0.636
Recurrence
Yes	62 (10.5)	42	20		61 (13.3)	42	19
No	529 (89.5)	187	342	< 0.001a	397 (86.7)	187	210	0.002a

¹Method = nearest; Cliper value = 0.02.

^aP < 0.05 was considered statistically significant.

HALP: Combination index of hemoglobin, albumin, lymphocyte, and platelet; HPF: High-power field; NIH: National Institutes of Health; PSM: Propensity scores matching; SD: Standard deviation.