Involvement of Met receptor pathway in aggressive behavior of colorectal cancer cells induced by parathyroid hormone-related peptide

Figure 10  Possible mechanism based on the action of parathyroid hormone-related peptide in the regulation of Met gene expression and its activation. The binding of parathyroid hormone-related peptide (PTHrP) to PTHR type 1 (PTHR1) in HCT116 cells promotes the up-regulation of Met gene expression. PTHrP also induces the activation of Met through Src kinase and the mitogen-activated protein kinases (MAPKs) pathway (Erk 1/2 MAPK and p38 MAPK). Once activated, Met signaling leads to molecular changes in the tumor cell that promote events related to the aggressive behavior of colorectal cancer cells. CRC: Colorectal cancer; Erk 1/2: Extracellular signal-regulated kinases 1/2; Met: Receptor tyrosine kinase Met; P: Activators domains phosphorylated; PTHR1: Parathyroid hormone receptor type 1; PTHrP: Parathyroid hormone-related peptide.