Fecal gene detection based on next generation sequencing for colorectal cancer diagnosis

Table 5 Comparison of pathogenic mutation sites in preoperative stools vs tumor tissues

Gene	Positive rate of pathogenic gene mutation sites
	Preoperative feces	Tumor tissues
TP53	37.04% (10/27)	46.00% (23/50)
APC	11.11% (3/27)	18.00% (9/50)
KRAS	25.93% (7/27)	54.00% (27/50)
PIK3CA	3.70% (1/27)	22.00% (11/50)
FBXW7	3.70% (1/27)	6.00% (3/50)
GNAS	3.70% (1/27)	4.00% (2/50)
PTEN	3.70% (1/27)	0
ABL1	3.70% (1/27)	0
PDGFRA	3.70% (1/27)	0
ATM	0	2.00% (1/50)
SMAD4	0	2.00% (1/50)
BRAF	0	2.00% (1/50)
PTPN11	0	2.00% (1/50)
NRAS	0	2.00% (1/50)
CTNNB1	0	2.00% (1/50)
VHL	3.70% (1/27)	0

Positive rate of pathogenic gene mutation site: The number of people with mutations corresponding to the pathogenic mutation sites of any gene/total number of samples.