Fecal gene detection based on next generation sequencing for colorectal cancer diagnosis

Table 12 "Undetected" gene mutation sites in tumor tissues

Gene	Location	Amino acid mutation	Mutation start position	Mutation end position	Number of cases	Undetected sites/total mutation sites
TP53	Exon 4	A84G	7579436	7579436	4
	Exon 5	P152A	7578476	7578476	1
	Exon 8	L289P	7577072	7577072	1	6/40
APC	Exon 17	S13461	112175328	112175328	1
		K1573fs	112175953	112175954	1
		E1327fs	112175213	112175217	1	3/15
FBXW7	Exon 7	R2781	153258983	153258983	1
	Exon 12	R266C	153247289	153247289	1	2/5
NOTCH1	Exon 26	R1599P	139399350	139399350	2	2/2
EGFR	Exon 20	I821T	55249164	55249164	1	1/2

¹Indicates stop codon.

fs: Frameshift mutation.