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©The Author(s) 2022.
World J Gastroenterol. Jul 7, 2022; 28(25): 2900-2909
Published online Jul 7, 2022. doi: 10.3748/wjg.v28.i25.2900
Published online Jul 7, 2022. doi: 10.3748/wjg.v28.i25.2900
Table 1 Transcribed ultraconserved region in gastric cancer
| T-UCR name | Location | Orientation | Expression in gastric cancer | Biological or molecular functions in gastric cancer | Ref. |
| Uc.63+ | Chr.2 | Sense | Downregulated | Associated with the classification and progression of gastric cancer | [14] |
| Uc.118 | Chr.3 | Antisense | Downregulated | - | [16] |
| Uc.158 | Chr.5 | Antisense | Downregulated | - | [16] |
| uc.160 | Chr.5 | Sense | Downregulated | Inhibits cell proliferation and promotes apoptosis in AGS and SGC-7901 cell lines, promoting gastric cancer tumourigenesis | [15,17] |
| Uc.241 | - | - | Downregulated | - | [16] |
| Uc.244 | Chr.8 | Sense | Down/upregulated | - | [16,23] |
| Uc.249 | Chr.9 | Sense | Down/upregulated | - | [16,23] |
| Uc.252 | Chr.9 | Antisense | Down/upregulated | - | [16,23] |
| Uc.261 | Chr.9 | Sense | Down/upregulated | - | [16,23] |
| Uc.282 | Chr.9 | Sense | Down/upregulated | - | [16,23] |
| Uc.283 | - | - | - | - | [16] |
| Uc.346 | Chr.12 | - | Downregulated | - | [23] |
| Uc.359 | Chr.14 | Antisense | Down/upregulated | - | [16,23] |
| Uc.416 | - | Antisense | Upregulated | Promotes proliferation in MKN-74 cell line, promoting gastric cancer tumourigenesis | [16] |
- Citation: Gao SS, Zhang ZK, Wang XB, Ma Y, Yin GQ, Guo XB. Role of transcribed ultraconserved regions in gastric cancer and therapeutic perspectives. World J Gastroenterol 2022; 28(25): 2900-2909
- URL: https://www.wjgnet.com/1007-9327/full/v28/i25/2900.htm
- DOI: https://dx.doi.org/10.3748/wjg.v28.i25.2900