Long noncoding RNAs in hepatitis B virus replication and oncogenesis

Table 2 Long noncoding RNAs downregulated in hepatitis B virus-related hepatocellular carcinoma

LncRNA name	Regulatory mechanism	Biological function
Dreh[84]	Inhibits the vimentin expression and alters its structure	Inhibits proliferation of HCC cells in vitro and tumor growth in vivo
LET[85]	LET/NF90/HIF1-α axis	Inhibits HCC invasion
uc.306[87]	May participate in the Wnt pathway	Not known
UPAT[88]	Promotes ZEB1 degradation	Suppresses cellular migration, invasion, and EMT processes
SEMA6A-AS1[89]	Not known	Not known
BANCR[90]	Not known	Not known
miR143HG[91]	Suppresses the MAPK and Wnt signaling pathways	Inhibits tumor multiplication and metastasis
LncRNA-6195[92]	Represses the enzymatic activity of ENO1	Represses the growth of HCC
LINC01352[93]	LINC01352/miR-135b/APC axis	Facilitates HCC progression
F11-AS1[94]	lncRNA F11-AS1/miR-211-5p/NR1l3 axis	Inhibits HCC growth and metastasis

LncRNAs: Long noncoding RNAs; HCC: Hepatocellular carcinoma; EMT: Epithelial-to-mesenchymal transition; HIF-1α: Hypoxia induced factor 1-α.