Inflammation, microbiome and colorectal cancer disparity in African-Americans: Are there bugs in the genetics?

doi:10.3748/wjg.v28.i25.2782

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 28, Issue 25

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (7217)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-3) series, Tables (1-2) series.

Item

Count

PDF

342

WORD

HTML

3554

Figures (1-3)

623

Tables (1-2)

426

Sum=5022

Featured Article

The chart showing Browse series, Download series.

Item

Count

Browse

256

Download

399

Sum=655

Publishing Process of This Article

Item

Count

Browse

438

Download

1102

Sum=1540

Jul 7, 2022 (publication date) through Nov 23, 2024

Times Cited of This Article

Times Cited (5)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Review

World J Gastroenterol. Jul 7, 2022; 28(25): 2782-2801
Published online Jul 7, 2022. doi: 10.3748/wjg.v28.i25.2782

Table 2 Interactions of host genetics (metabolic and immune-related single nucleotide polymorphism) with gut bacteria

Ref.	Size	Analysis	Gene	SNP	Function	Bacteria	Ethnicity	Comment
Knights et al[59], 2014	474 IBD	16S RNA	NOD2	rs5743293, rs104895431, rs104895467, rs2068844, rs2068845, rs5743277, rs5743293	Innate immunity	Enterobacteriaceae	Europeans	IBD
Blekhman et al[122], 2015	93 (HMP)	Metagenomic	LCT	rs2304371, rs3754689	Metabolism	Bifidobacterium, SMB53 (Clostridiaceae)	Multi-ethnic	NS
Blekhman et al[122], 2015	93 (HMP)	Metagenomic	GNA12	rs1182182	IBD	Bifidobacterium, SMB53 (Clostridiaceae)	Multi-ethnic	NS
Goodrich et al[123], 2016	1126	Fecal 16S rRNA	CD36	rs1360741	Immune-related	Blautia	Europeans	United Kingdom twins
Li et al[137], 2016	10523 IBD, 5726 IBD	Mucosal 16S rRNA	SLC39A8	rs13107325	Immune-related	Composition	ND	IBD
Bonder et al[68], 2016	1514	Metagenomic	C11orf30-LRRC32	rs2155219	IBD	Coprococcus comes/Proteobacteria		AA¹ PCa risk
			CCL2	rs3091315, rs3091316	Immune-related	Methonobacteria
			DAP2	rs267939	Innate immunity	Bifidobacterium
			IL23R	rs12141575	Immune-related	Enterobacteriaceae/E. coli
			IL10	rs1800871¹	Immune-related	Proteobacteria/Sutterella
			MUC22	rs3873352	Barrier defense
			NOD1	rs12669082	Innate immunity	Enterobacteriaceae/E.coli
				rs41524946	Innate immunity	Enteroba cteriaceae/E. coli
				rs55689059	Innate immunity	Enterobacteriaceae/E. coli
				rs55841603	Innate immunity	Enterobacteriaceae/E. coli
			NOD2	rs8056611, rs2357792,	Innate immunity	Enterobacteriaceae/E. coli
			CD209	rs1010046	Innate immunity	Bacteroidetes
Rühlemann et al[138], 2021	8956	16S rRNA/GWAS	FUT2	rs602662	Barrier defense	Bacteroides OTU97_27	Europeans
Rühlemann et al[138], 2021	8956	16S rRNA/GWAS	BLVRA	rs623108	Innate immunity	Barnesiella spp. OTU99_55	Europeans

¹Studies include an analysis according to the population origins.

AA: African-American; GWAS: Genome-wide association studies; HMP: Human Microbiome Project; IBD: Inflammatory bowel disease; SNP: Single nucleotide polymorphism; ND: Not determined; NS: Not significant; PCa: Prostate cancer; rRNA: Ribosomal RNA; E. coli: Escherichia coli; FUT2: Fucosyltransferase 2; NOD2: Nucleotide binding oligomerization domain containing protein 2; LCT: Lactase; GNA12: Guanine nucleotide-binding protein alpha-12; CCL2: C-C motif chemokine ligand 2; IL: Interleukin; MUC22: Mucin 22; BLVRA: Biliverdin reductase.

Citation: Ahmad S, Ashktorab H, Brim H, Housseau F. Inflammation, microbiome and colorectal cancer disparity in African-Americans: Are there bugs in the genetics? World J Gastroenterol 2022; 28(25): 2782-2801
URL: https://www.wjgnet.com/1007-9327/full/v28/i25/2782.htm
DOI: https://dx.doi.org/10.3748/wjg.v28.i25.2782