Inflammation, microbiome and colorectal cancer disparity in African-Americans: Are there bugs in the genetics?

doi:10.3748/wjg.v28.i25.2782

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World Journal of Gastroenterology

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World J Gastroenterol. Jul 7, 2022; 28(25): 2782-2801
Published online Jul 7, 2022. doi: 10.3748/wjg.v28.i25.2782

Table 2 Interactions of host genetics (metabolic and immune-related single nucleotide polymorphism) with gut bacteria

Ref.	Size	Analysis	Gene	SNP	Function	Bacteria	Ethnicity	Comment
Knights et al[59], 2014	474 IBD	16S RNA	NOD2	rs5743293, rs104895431, rs104895467, rs2068844, rs2068845, rs5743277, rs5743293	Innate immunity	Enterobacteriaceae	Europeans	IBD
Blekhman et al[122], 2015	93 (HMP)	Metagenomic	LCT	rs2304371, rs3754689	Metabolism	Bifidobacterium, SMB53 (Clostridiaceae)	Multi-ethnic	NS
Blekhman et al[122], 2015	93 (HMP)	Metagenomic	GNA12	rs1182182	IBD	Bifidobacterium, SMB53 (Clostridiaceae)	Multi-ethnic	NS
Goodrich et al[123], 2016	1126	Fecal 16S rRNA	CD36	rs1360741	Immune-related	Blautia	Europeans	United Kingdom twins
Li et al[137], 2016	10523 IBD, 5726 IBD	Mucosal 16S rRNA	SLC39A8	rs13107325	Immune-related	Composition	ND	IBD
Bonder et al[68], 2016	1514	Metagenomic	C11orf30-LRRC32	rs2155219	IBD	Coprococcus comes/Proteobacteria		AA¹ PCa risk
			CCL2	rs3091315, rs3091316	Immune-related	Methonobacteria
			DAP2	rs267939	Innate immunity	Bifidobacterium
			IL23R	rs12141575	Immune-related	Enterobacteriaceae/E. coli
			IL10	rs1800871¹	Immune-related	Proteobacteria/Sutterella
			MUC22	rs3873352	Barrier defense
			NOD1	rs12669082	Innate immunity	Enterobacteriaceae/E.coli
				rs41524946	Innate immunity	Enteroba cteriaceae/E. coli
				rs55689059	Innate immunity	Enterobacteriaceae/E. coli
				rs55841603	Innate immunity	Enterobacteriaceae/E. coli
			NOD2	rs8056611, rs2357792,	Innate immunity	Enterobacteriaceae/E. coli
			CD209	rs1010046	Innate immunity	Bacteroidetes
Rühlemann et al[138], 2021	8956	16S rRNA/GWAS	FUT2	rs602662	Barrier defense	Bacteroides OTU97_27	Europeans
Rühlemann et al[138], 2021	8956	16S rRNA/GWAS	BLVRA	rs623108	Innate immunity	Barnesiella spp. OTU99_55	Europeans

¹Studies include an analysis according to the population origins.

AA: African-American; GWAS: Genome-wide association studies; HMP: Human Microbiome Project; IBD: Inflammatory bowel disease; SNP: Single nucleotide polymorphism; ND: Not determined; NS: Not significant; PCa: Prostate cancer; rRNA: Ribosomal RNA; E. coli: Escherichia coli; FUT2: Fucosyltransferase 2; NOD2: Nucleotide binding oligomerization domain containing protein 2; LCT: Lactase; GNA12: Guanine nucleotide-binding protein alpha-12; CCL2: C-C motif chemokine ligand 2; IL: Interleukin; MUC22: Mucin 22; BLVRA: Biliverdin reductase.

Citation: Ahmad S, Ashktorab H, Brim H, Housseau F. Inflammation, microbiome and colorectal cancer disparity in African-Americans: Are there bugs in the genetics? World J Gastroenterol 2022; 28(25): 2782-2801
URL: https://www.wjgnet.com/1007-9327/full/v28/i25/2782.htm
DOI: https://dx.doi.org/10.3748/wjg.v28.i25.2782