Inflammation, microbiome and colorectal cancer disparity in African-Americans: Are there bugs in the genetics?

doi:10.3748/wjg.v28.i25.2782

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 28, Issue 25

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (7217)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-3) series, Tables (1-2) series.

Item

Count

PDF

342

WORD

HTML

3554

Figures (1-3)

623

Tables (1-2)

426

Sum=5022

Featured Article

The chart showing Browse series, Download series.

Item

Count

Browse

256

Download

399

Sum=655

Publishing Process of This Article

Item

Count

Browse

438

Download

1102

Sum=1540

Jul 7, 2022 (publication date) through Nov 23, 2024

Times Cited of This Article

Times Cited (5)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Review

World J Gastroenterol. Jul 7, 2022; 28(25): 2782-2801
Published online Jul 7, 2022. doi: 10.3748/wjg.v28.i25.2782

Table 1 Immune-related single nucleotide polymorphism associated with colorectal cancer

Ref.	Size	Analysis	Gene	SNP	Function	Ethnicity	Comment
Montazeri et al[89], 2020	6149 CRC 7337 controls	Meta-analysis	COLCA1/2¹	rs3802842 (11q23.1)	Immune infiltration of LP	Europeans	Confirmed by Lu et al[49], 2019¹
Montazeri et al[89], 2020	6149 CRC 7337 controls	Meta-analysis	TGFB1, SMAD7,SMAD7	rs1800469, rs12953717, rs4464148	TGFB signaling inhibitor	Europeans	Confirmed by Lu et al[49], 2019¹
Law et al[50], 2019	34627 CRC 71379 controls	Meta-analysis	HLA-C	rs3131043 (6p21.33)	Adaptive immunity	Europeans
			HLA-DRB1/DQA1	rs9271770 (6q21.33)	Adaptive immunity
			COLCA1/2	rs3087967 (11q23.1)	Immune LP leukocytes
			FUT2	rs12979278 (19q13.33)	Gut barrier
Lu et al[49], 2019		GWAS	NOD2	rs2066847	Innate immunity	East Asians	Confirmed by Montazeri et al[89], 2020²
			GATA3	rs10795668 (10p14)	T cell transcription factor
			SMAD7	rs7229639	TGFB signaling inhibitor
			SMAD7	rs4939827	TGFB signaling inhibitor
			COLCA1/2²	rs3802842 (11q23.1)	Immune infiltration of LP
Sanabria-Salas et al[33], 2017	391 CRC	GWAS	IL1B	CGTC haplotype (2q14)	Inflammation	Columbian Africans	Association with AA admixture
Hung et al[85], 2015	15414 CRC 17688 controls	GWAS	SH2B3	rs3184504 (12q24)	Cytokine signaling	Europeans	Confirmed by Schumacher et al[135], 2015
Schumacher et al[135], 2015	18299 CRC, 19656 controls (Europeans), 2098 cases, 6172 controls (Asian 1), 2627 cases, 3797 controls (Asian 2)	Meta-analysis	SH2B3³	rs3184504 (12q24.12)	Cytokine signaling	Europeans/Asians	Confirmed by Hung et al[85], 2015³
Schumacher et al[135], 2015		Meta-analysis	NOS1	rs73208120 (12q24.22)	ROS production	Europeans/Asians	Confirmed by Hung et al[85], 2015³
Wang et al[47], 2013	2535 CRC, 3915 controls (discovery), 2153 CRC, 2630 controls (validation)	GWAS	PPARG	rs9858822	Monocyte activation	Multi-ethnic	High frequency in AA
Tsilidis et al[136], 2009	CLUE II cohort, 208 CRC, 381 controls	GWAS	IL10	rs1800896, rs1800890, rs3024496, rs3024498	Increased IL-10	ND

¹Confirmed by Lu et al[49].

²Confirmed by Montazeri et al[89].

³Confirmed by Hung et al[85].

AA: African-American; CRC: Colorectal cancer; GWAS: Genome-wide association studies; IL: Interleukin; LP: Lamina propria; ROS: Reactive oxygen species; SNP: Single nucleotide polymorphism; TGF: Transforming growth factor; ND: Not determined; HLA: Human leukocyte antigen; FUT2: Fucosyltransferase 2; NOD2: Nucleotide binding oligomerization domain containing protein 2; GATA3: GATA binding protein 3; SH2B3: SH2B adapter protein 3; NOS1: Nitric oxide synthase 1; PPARG: Peroxisome proliferator-activated receptor gamma.

Citation: Ahmad S, Ashktorab H, Brim H, Housseau F. Inflammation, microbiome and colorectal cancer disparity in African-Americans: Are there bugs in the genetics? World J Gastroenterol 2022; 28(25): 2782-2801
URL: https://www.wjgnet.com/1007-9327/full/v28/i25/2782.htm
DOI: https://dx.doi.org/10.3748/wjg.v28.i25.2782