Inflammation, microbiome and colorectal cancer disparity in African-Americans: Are there bugs in the genetics?

doi:10.3748/wjg.v28.i25.2782

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World Journal of Gastroenterology

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World J Gastroenterol. Jul 7, 2022; 28(25): 2782-2801
Published online Jul 7, 2022. doi: 10.3748/wjg.v28.i25.2782

Table 1 Immune-related single nucleotide polymorphism associated with colorectal cancer

Ref.	Size	Analysis	Gene	SNP	Function	Ethnicity	Comment
Montazeri et al[89], 2020	6149 CRC 7337 controls	Meta-analysis	COLCA1/2¹	rs3802842 (11q23.1)	Immune infiltration of LP	Europeans	Confirmed by Lu et al[49], 2019¹
Montazeri et al[89], 2020	6149 CRC 7337 controls	Meta-analysis	TGFB1, SMAD7,SMAD7	rs1800469, rs12953717, rs4464148	TGFB signaling inhibitor	Europeans	Confirmed by Lu et al[49], 2019¹
Law et al[50], 2019	34627 CRC 71379 controls	Meta-analysis	HLA-C	rs3131043 (6p21.33)	Adaptive immunity	Europeans
			HLA-DRB1/DQA1	rs9271770 (6q21.33)	Adaptive immunity
			COLCA1/2	rs3087967 (11q23.1)	Immune LP leukocytes
			FUT2	rs12979278 (19q13.33)	Gut barrier
Lu et al[49], 2019		GWAS	NOD2	rs2066847	Innate immunity	East Asians	Confirmed by Montazeri et al[89], 2020²
			GATA3	rs10795668 (10p14)	T cell transcription factor
			SMAD7	rs7229639	TGFB signaling inhibitor
			SMAD7	rs4939827	TGFB signaling inhibitor
			COLCA1/2²	rs3802842 (11q23.1)	Immune infiltration of LP
Sanabria-Salas et al[33], 2017	391 CRC	GWAS	IL1B	CGTC haplotype (2q14)	Inflammation	Columbian Africans	Association with AA admixture
Hung et al[85], 2015	15414 CRC 17688 controls	GWAS	SH2B3	rs3184504 (12q24)	Cytokine signaling	Europeans	Confirmed by Schumacher et al[135], 2015
Schumacher et al[135], 2015	18299 CRC, 19656 controls (Europeans), 2098 cases, 6172 controls (Asian 1), 2627 cases, 3797 controls (Asian 2)	Meta-analysis	SH2B3³	rs3184504 (12q24.12)	Cytokine signaling	Europeans/Asians	Confirmed by Hung et al[85], 2015³
Schumacher et al[135], 2015		Meta-analysis	NOS1	rs73208120 (12q24.22)	ROS production	Europeans/Asians	Confirmed by Hung et al[85], 2015³
Wang et al[47], 2013	2535 CRC, 3915 controls (discovery), 2153 CRC, 2630 controls (validation)	GWAS	PPARG	rs9858822	Monocyte activation	Multi-ethnic	High frequency in AA
Tsilidis et al[136], 2009	CLUE II cohort, 208 CRC, 381 controls	GWAS	IL10	rs1800896, rs1800890, rs3024496, rs3024498	Increased IL-10	ND

¹Confirmed by Lu et al[49].

²Confirmed by Montazeri et al[89].

³Confirmed by Hung et al[85].

AA: African-American; CRC: Colorectal cancer; GWAS: Genome-wide association studies; IL: Interleukin; LP: Lamina propria; ROS: Reactive oxygen species; SNP: Single nucleotide polymorphism; TGF: Transforming growth factor; ND: Not determined; HLA: Human leukocyte antigen; FUT2: Fucosyltransferase 2; NOD2: Nucleotide binding oligomerization domain containing protein 2; GATA3: GATA binding protein 3; SH2B3: SH2B adapter protein 3; NOS1: Nitric oxide synthase 1; PPARG: Peroxisome proliferator-activated receptor gamma.

Citation: Ahmad S, Ashktorab H, Brim H, Housseau F. Inflammation, microbiome and colorectal cancer disparity in African-Americans: Are there bugs in the genetics? World J Gastroenterol 2022; 28(25): 2782-2801
URL: https://www.wjgnet.com/1007-9327/full/v28/i25/2782.htm
DOI: https://dx.doi.org/10.3748/wjg.v28.i25.2782