Novel multiplex stool-based assay for the detection of early-stage colon cancer in a Chinese population

Figure 3 Differentially methylated region analysis and biomarkers discovery. A: Volcano plot of differentially methylated regions (DMRs) in cancer sample group (CSG) vs healthy sample group (HSG); B: The distribution of the identified DMRs in the genome in relation to cytosine-guanine islands (CGIs); C: Circos plot of 2531 candidate DMRs on each of the 22 autosomes and the X chromosome; D: Kyoto Encyclopedia of Genes and Genomes pathway analysis of 2062 DMR-related genes; E: Gene Ontology analysis of 2062 DMR-related genes; F: Venn diagram of the overlapping target DMRs among different signatures. ^aP < 0.05. DMRs: Differentially methylated regions; CGI: Cytosine-guanine islands.