Downregulation of TNFR2 decreases survival gene expression, promotes apoptosis and affects the cell cycle of gastric cancer cells

Figure 3 Relative expression of miRNAs related to the tumour necrosis factor-α pathway. Expression levels of miR-19a, miR-34a, miR-103a, miR-130a and miR-181c in nonsilenced AGS, AGS with TNFR1 downregulation (shTNFR1), and AGS with TNFR2 downregulation (shTNFR2) either not treated (control) or treated with the Helicobacter pylori extract. A: miR-19a; B: miR-34a; C: miR-103a; D: miR-130a; E: miR-181c. Bars represent the mean ± SD from three independent trials. The dotted line indicates relative quantification: RQ = 1.0. Statistically significant difference: ^aP < 0.05; ^bP < 0.01; ^cP < 0.001. eHP: Helicobacter pylori extract.