Drug-induced autoimmune hepatitis: A minireview

Figure 3 Liver biopsy findings for patient B. A: Low power view [hematoxylin & eosin (H&E) 100 ×] shows portal and lobular inflammation with lobular disarray and mild steatosis; B: Higher magnification of the portal tract (H&E 200 ×) demonstrates moderate plasma cell-rich chronic inflammation with continuous interface damage; C: Lobulitis with aggregates of plasma cells and rosetting of hepatocytes is present in the lobule (H&E 200 ×); D and E: Masson trichrome (D, 40 ×) and Victoria blue (E, 40 ×) display mild early young fibrosis and paucity of elastic fibers, respectively. The absence of old mature type fibrosis suggested not a chronic injury. The autoimmune hepatitis histological pattern observed was therefore interpreted to be drug related, atorvastatin-induced.