Usefulness of serum C-reactive protein and calprotectin for the early detection of colorectal anastomotic leakage: A prospective observational study

Table 6 Summary of the predictive performance of the studied plasma biomarkers

	AUROC	Cut-off value	SS	SP	NPV	PPV	PLR	NLR
WBC in g/L
POD3	0.57	9.75	0.46	0.75	0.95	0.11	1.84	0.72
POD4	0.60	8.25	0.52	0.68	0.96	0.10	1.64	0.70
POD5	0.62	7.55	0.56	0.62	0.95	0.09	1.48	0.71
ECC in cells/μL
POD3	0.59	150	0.50	0.59	0.95	0.08	1.23	0.84
POD4	0.54	150	0.33	0.71	0.94	0.07	1.14	0.94
POD5	0.70	250	0.89	0.43	0.98	0.10	1.55	0.26
CRP in mg/L
POD3	0.76	175.90	0.64	0.83	0.97	0.20	3.77	0.44
POD4	0.76	152.40	0.62	0.89	0.97	0.27	5.40	0.43
POD5	0.81	96.80	0.78	0.78	0.98	0.19	3.48	0.29
PCT in ng/mL
POD3	0.57	0.19	0.68	0.47	0.96	0.08	1.28	0.68
POD4	0.50	0.31	0.38	0.76	0.95	0.10	1.56	0.82
POD5	0.61	0.39	0.44	0.79	0.96	0.12	2.10	0.71
CLP in μg/mL
POD3	0.78	6.57	0.71	0.72	0.97	0.15	2.55	0.40
POD4	0.67	8.34	0.56	0.86	0.97	0.21	3.89	0.51
POD5	0.65	6.98	0.58	0.80	0.97	0.16	2.84	0.52

AUROC: Area under the receiver operating characteristic curve; SS: Sensitivity; SP: Specificity; NPV: Negative predictive value; PPV: Positive predictive value; PLR: Positive likelihood ratio; NLR: Negative likelihood ratio; WBC: White blood cell count; POD: Postoperative day; ECC: Eosinophil cell count; CRP: C-reactive protein; PCT: Procalcitonin; CLP: Calprotectin.