Usefulness of serum C-reactive protein and calprotectin for the early detection of colorectal anastomotic leakage: A prospective observational study

Table 5 Intraoperative and postoperative details of patients with colorectal anastomotic leakage (minor vs major)

	Minor CAL, n = 7	Major CAL, n = 18	P value
Type of anastomosis, n (%)			0.52
Intrabdominal	3 (42.8)	9 (50.0)
Pelvic	4 (57.2)	9 (50.0)
Covering stoma, n (%)	1 (14.3)	1 (5.6)	0.47
Abdominal pain
POD3	1.86	1.94	0.08
POD4	1.57	2.13	0.04
POD5	1.86	1.92	0.03
Clinical condition
POD3	1	1.25	0.07
POD4	1.14	1.47	0.13
POD5	1.29	1.58	0.02
CRP levels in mg/L
POD3	178.35	221.02	0.28
POD4	146.30	226.01	0.13
POD5	107.64	251.45	0.01
CLP levels in μg/mL
POD3	2.75	12.99	< 0.001
POD4	3.34	10.60	0.01
POD5	2.52	10.96	0.004
CAL diagnosis in d, median	8	5.5	0.07
Diagnostic method, n (%)			0.12
Clinical	0 (0)	7 (38.9)
Abdominopelvic CT	7 (100)	11 (61.1)
CAL management, n (%)			< 0.001
Drainage	NA	2 (11.1)
Reoperation		16 (88.9)
LOHS in d, mean ± SD	28.0 ± 17.0	22.4 ± 12.9	0.38

CAL: Colorectal anastomotic leakage; POD: Postoperative day; CRP: C-reactive protein; CLP: Calprotectin; CT: Computed tomography; LOHS: Length of hospital stay; NA: Not applicable.