Radiomic analysis based on multi-phase magnetic resonance imaging to predict preoperatively microvascular invasion in hepatocellular carcinoma

Table 4 Receiver operating characteristic results of radiomic analysis based on most discriminant factors in portal venous phase and histogram parameters to discriminate between microvascular invasion+ and microvascular invasion- groups

	MVI (-)	MVI (+)	AUC	Sensitivity	Specificity	P value	Cut-off value
MDF	(7.84 ± 9.26) × 10-3	(-4.30 ± 7.00) × 10-3	0.85 (0.81-0.90)	67%	90%	< 0.001	4.17 × 10-3
Histogram parameters
Mean	(1.24 ± 0.24) × 102	(1.08 ± 0.24) × 102	0.69 (0.63-0.75)	78%	54%	< 0.001	106.6
Variance	(3.07 ± 4.11) × 102	(4.30 ± 3.59) × 102	0.67 (0.61-0.74)	80%	50%	< 0.001	165.9
Skewness	(1.93 ± 6.11) × 10-1	(1.87 ± 5.85) × 10-1	0.50 (0.44-0.57)	16%	88%	0.09	7.76 × 10-1
Kurtosis	(0.60 ± 1.20)	(0.62 ± 1.19)	0.51 (0.44-0.57)	57%	51%	0.787	1.62 × 10-1
Perc.01%	(91.84 ± 30.33)	(67.16 ± 24.85)	0.74 (0.68-0.80)	50%	90%	< 0.001	101.5
Perc.10%	(1.06 ± 0.29) × 102	(0.84 ± 0.25) × 102	0.72 (0.67-0.78)	56%	81%	< 0.001	107.5
Perc.50%	(1.25 ± 0.24) × 102	(1.07 ± 0.24) × 102	0.69 (0.64-0.75)	78%	55%	< 0.001	106.5
Perc.90%	(1.44 ± 0.27) × 102	(1.32 ± 0.27) × 102	0.62 (0.56-0.68)	63%	61%	< 0.001	137.5
Perc.99%	(1.61 ± 0.31) × 102	(1.56 ± 0.34) × 102	0.55 (0.49-0.61)	35%	77%	0.179	176.5

AUC: Area under the receiver operating characteristic curve; MDF: Most discriminant factor; MVI: Microvascular invasion.