Radiomic analysis based on multi-phase magnetic resonance imaging to predict preoperatively microvascular invasion in hepatocellular carcinoma

Table 3 Receiver operating characteristic results of radiomic analysis based on most discriminant factors in arterial phase and histogram parameters to discriminate between microvascular invasion+ and microvascular invasion- groups

	MVI (-)	MVI (+)	AUC	Sensitivity	Specificity	P value	Cut-off value
MDF	(-4.80 ± 6.14) × 10-2	(2.63 ± 4.74) × 10-2	0.84 (0.80-0.88)	87%	66%	< 0.001	1.97 × 10-2
Histogram parameters
Mean	(1.27 ± 0.28) × 102	(1.09 ± 0.26) × 102	0.68 (0.63-0.74)	78%	52%	< 0.001	1.06 × 102
Variance	(5.28 ± 4.24) × 102	(4.57 ± 3.21) × 102	0.54 (0.48-0.61)	68%	45%	0.204	3.32 × 102
Skewness	(-9.71 ± 58.46) × 10-2	(2.52 ± 5.79) × 10-1	0.68 (0.62-0.74)	76%	58%	< 0.001	1.30 × 10-1
Kurtosis	(-5.24 ± 91.73) × 10-2	(4.06 ± 11.19) × 10-1	0.60 (0.53-0.66)	90%	25%	0.004	-5.96 × 10-1
Perc.01%	(0.80 ± 0.20) × 102	(0.68 ± 0.20) × 102	0.68 (0.62-0.74)	78%	50%	< 0.001	64.5
Perc.10%	(0.99 ± 0.23) × 102	(0.84 ± 0.22) × 102	0.68 (0.62-0.74)	96%	32%	< 0.001	69.5
Perc.50%	(1.28 ± 0.30) × 102	(1.08 ± 0.27) × 102	0.69 (0.63-0.74)	76%	47%	< 0.001	105.5
Perc.90%	(1.54 ± 0.34) × 102	(1.35 ± 0.31) × 102	0.65 (0.59-0.71)	57%	70%	< 0.001	148.5
Perc.99%	(1.73 ± 0.39) × 102	(1.57 ± 0.35) × 102	0.62 (0.55-0.68)	48%	74%	< 0.001	177.5

AUC: Area under the receiver operating characteristic curve; MDF: Most discriminant factor; MVI: Microvascular invasion.