Rebuilding trust in proton pump inhibitor therapy

Table 1 Type of proton pump inhibitor available

PPI	Omeprazole	Esomeprazole	Lansoprazole	Dexlansoprazole	Pantoprazole	Rabeprazole
Half-life (T1/2) (hrs)[7-9]	0.6-1.0[7]	1.1[8]	0.9-1.6[7]	1-2[9]	0.9-1.9[7]	1[7]
Hepatic metabolism[10]	Major: CYP2C19; minor: CYP3A4	Major: CYP2C19; minor: CYP3A4	Major: CYP2C19; minor: CYP3A4	Major: CYP2C19; minor: CYP3A4	Minor: CYP3A4 CYP2C19	Non-enzymatic reduction minor: CYP2C19 and CYP3A4
Elimination[11]	Renal	Renal	Renal/fecal	Renal/fecal	Renal	Renal
Oral bioavailability (%)[11]	40-50	89	80-90	50-60	77	52
Food effect[14]	30 min before breakfast	60 min before breakfast	30 min before breakfast	Pharmacokinetics unaffected by meals	Pharmacokinetics unaffected by meals (exception oral suspension: 30 min prior to meal)	Pharmacokinetics unaffected by meals (exception capsule sprinkle: 30 min prior to meal)

PPI: Proton pump inhibitor.