Copyright
©The Author(s) 2022.
World J Gastroenterol. Jun 21, 2022; 28(23): 2527-2545
Published online Jun 21, 2022. doi: 10.3748/wjg.v28.i23.2527
Published online Jun 21, 2022. doi: 10.3748/wjg.v28.i23.2527
Patient number | 1 | 2 | 3 |
Sex | Female | Female | Female |
SLE Dx age | 19 | 50 | 20 |
ACR criteria | 8/11 | 7/11 | 8/11 |
AIH Dx age | 26 | 37 | 22 |
IAIHG score | Definite | Definite | Definite |
Clinical | |||
SLE | Skin, joint, renal, hematology, neurology | Skin, joint, renal, hematology, serositis | Skin, joint, renal, hematology, serositis |
AILD complication | Jaundice, malaise LC with PH | Jaundice, pruritus hepatosplenomegaly | Jaundice, anorexia |
Coexistent AID | Nil | PBC, SS | Nil |
Laboratory | |||
Hemogram | HA, TP | HA, TP, leukopenia | TP, leukopenia |
Proteinuria autoantibody | 2 g/d | 2.5 g/d | 1 g/d |
SLE-related | ANA, anti-dsDNA/Sm | ANA, anti-dsDNA/Sm | ANA, anti-dsDNA |
AILD-related | ASMA | AMA, ASMA | ASMA |
Others | ARPA, ANCA | ARPA, anti-Ro/La | ARPA |
2IgG (mg/dL) | 2130 | 2520 | 1615 |
2AST (IU/L) | 1563 | 116 | 97 |
2ALT (IU/L) | 1093 | 217 | 177 |
2Bil (mg/dL) | 23.8 | 3.7 | 2.4 |
2ALP (IU/L) | 432 | 621 | 344 |
HLA-DR | DR8, DR15 | DR4, DR15 | DR4, DR7 |
VH | No 3HHV/CMV/EBV | No HHV/CMV/EBV | No HHV/CMV/EBV |
Treatment | CS/AZA, LDLT and low-dose CS/FK506 after OP | CS/AZA, UDCA RTX and low-dose CS for maintenance | CS/AZA, AZA for maintenance |
Outcome | Stabilized LFT and low SLEDAI | Normalized LFT and low SLEDAI | Normalized LFT and low SLEDAI |
- Citation: Wang CR, Tsai HW. Autoimmune liver diseases in systemic rheumatic diseases. World J Gastroenterol 2022; 28(23): 2527-2545
- URL: https://www.wjgnet.com/1007-9327/full/v28/i23/2527.htm
- DOI: https://dx.doi.org/10.3748/wjg.v28.i23.2527