Differentiating malignant and benign focal liver lesions in children using CEUS LI-RADS combined with serum alpha-fetoprotein

Table 5 Performance of various diagnostic criteria for differentiating benign and malignant focal liver lesions

Diagnostic criteria	Sensitivity (%)	Specificity (%)	Accuracy (%)	AUC
Criterion I	100.0 (84.6-100.0)	29.3 (16.1-45.5)	54.0 (40.9-66.6)	0.646 (0.516-0.763)
Criterion II	63.6 (40.7-82.8)	95.1 (83.5-99.4)	84.1 (72.7-92.1)	0.794 (0.673-0.885)
Criterion III	100.0 (84.6-100.0)	80.5 (65.1-91.2)	87.3 (76.5-94.4)	0.902 (0.801-0.963)

Criterion I considered LR-4, LR-5, or LR-M lesions as malignancies; criterion II regarded LR-4, LR-5 or LR-M lesions with simultaneously elevated alpha-fetoprotein (AFP, ≥ 20 ng/mL) as malignancies; criterion III took LR-4 lesions with elevated AFP or LR-5 or LR-M lesions as malignancies. AUC: Area under the curve.