Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome: A multicenter retrospective study

doi:10.3748/wjg.v28.i21.2334

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Jun 7, 2022 (publication date) through Nov 4, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

World J Gastroenterol. Jun 7, 2022; 28(21): 2334-2349
Published online Jun 7, 2022. doi: 10.3748/wjg.v28.i21.2334

Table 4 Association of depressive, anxiety, and somatization symptoms with the single-nucleotide polymorphism score of the four tested polymorphisms

	Total	Sex		IBS subtypes
	Total	Male	Female	IBS-C	IBS-D	IBS-M
Depressive symptoms
F value	7.710	1.336	5.770	1.551	2.159	0.196
P-linear trend value	0.006	0.250	0.017	0.184	0.144	0.659
Anxiety symptoms
F value	2.150	0.028	2.514	1.372	2.400	1.412
P-linear trend value	0.143	0.866	0.114	0.245	0.123	0.236
Somatization symptoms
F value	1.15	0.354	1.028	0.716	2.718	0.628
P-linear trend value	0.283	0.553	0.311	0.614	0.102	0.429

Values in bold were “nominally significant” (i.e., lacking significance after false discovery rate multiple testing correction). IBS: Irritable bowel syndrome; IBS-C: Constipation-predominant IBS; IBS-D: Diarrhea-predominant IBS; IBS-M: IBS with mixed bowel habits.

Citation: Berens S, Dong Y, Fritz N, Walstab J, D'Amato M, Zheng T, Wahl V, Boekstegers F, Bermejo JL, Martinez C, Schmitteckert S, Clevers E, Engel F, Gauss A, Herzog W, Spiller R, Goebel-Stengel M, Mönnikes H, Andresen V, Thomas F, Keller J, Pehl C, Stein-Thöringer C, Clarke G, Dinan TG, Quigley EM, Sayuk G, Simrén M, Tesarz J, Rappold G, van Oudenhove L, Schaefert R, Niesler B. Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome: A multicenter retrospective study. World J Gastroenterol 2022; 28(21): 2334-2349
URL: https://www.wjgnet.com/1007-9327/full/v28/i21/2334.htm
DOI: https://dx.doi.org/10.3748/wjg.v28.i21.2334