Retrospective Study
Copyright ©The Author(s) 2022.
World J Gastroenterol. Jun 7, 2022; 28(21): 2334-2349
Published online Jun 7, 2022. doi: 10.3748/wjg.v28.i21.2334
Table 3 Differences between single-nucleotide polymorphisms in depressive and anxiety symptoms, separately analyzed with ANOVA using the dominant model and the recessive model
Models
Mental symptoms
SNPs
Total
Sex
IBS subtypes
Male
Female
IBS-C
IBS-D
IBS-M
Dominant modelDepressive symptomsHTR3A c.-42C>T (rs1062613)2.5414.149 ↑02860.9980.3760.694
HTR3B c.386A>C (rs1176744)0.0670.0050.1980.2820.1240.232
HTR3C c.489C>A (rs6766410)7.475 ↑0.6727.040 ↑0.2615.670 ↑2.328
HTR3E c.*76G>A (rs62625044)0.0540.0130.1800.2080.4610.010
Anxiety symptomsHTR3A c.-42C>T (rs1062613)0.5110.2100.2800.6040.6720.162
HTR3B c.386A>C (rs1176744)0.9260.4060.8010.4681.3690.770
HTR3C c.489C>A (rs6766410)6.535 ↑0.1587.550 ↑0.18613.444 ↑0.045
HTR3E c.*76G>A (rs62625044)1.0550.4290.8530.0000.4951.109
Somatization symptomsHTR3A c.-42C>T (rs1062613)0.0160.1410.1060.0860.0170.203
HTR3B c.386A>C (rs1176744)0.2170.3320.3260.4070.4152.125
HTR3C c.489C>A (rs6766410)0.7840.0351.0850.2690.0001.962
HTR3E c.*76G>A (rs62625044)0.0021.5540.2630.1280.7290.354
Recessive modelDepressive symptomsHTR3A c.-42C>T (rs1062613)0.0020.4210.1320.0931.3201.064
HTR3B c.386A>C (rs1176744)1.1182.0270.1071.7410.1970.744
HTR3C c.489C>A (rs6766410)0.0470.8210.4012.3066.190 ↑0.676
HTR3E c.*76G>A (rs62625044)0.677-0.5740.541--
Anxiety symptomsHTR3A c.-42C>T (rs1062613)0.4790.0270.5490.0570.3150.350
HTR3B c.386A>C (rs1176744)0.8720.0811.6910.4760.3611.923
HTR3C c.489C>A (rs6766410)0.0282.5620.3440.5703.5092.093
HTR3E c.*76G>A (rs62625044)0.216-0.1790.242--
Somatization symptomsHTR3A c.-42C>T (rs1062613)0.2170.0180.2570.1380.0920.431
HTR3B c.386A>C (rs1176744)6.482 ↑2.2453.5750.14214.033 ↑0.341
HTR3C c.489C>A (rs6766410)0.4681.8130.1284.715 ↓0.0020.113
HTR3E c.*76G>A (rs62625044)0.001-0.0110.000--

  • Citation: Berens S, Dong Y, Fritz N, Walstab J, D'Amato M, Zheng T, Wahl V, Boekstegers F, Bermejo JL, Martinez C, Schmitteckert S, Clevers E, Engel F, Gauss A, Herzog W, Spiller R, Goebel-Stengel M, Mönnikes H, Andresen V, Thomas F, Keller J, Pehl C, Stein-Thöringer C, Clarke G, Dinan TG, Quigley EM, Sayuk G, Simrén M, Tesarz J, Rappold G, van Oudenhove L, Schaefert R, Niesler B. Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome: A multicenter retrospective study. World J Gastroenterol 2022; 28(21): 2334-2349
  • URL: https://www.wjgnet.com/1007-9327/full/v28/i21/2334.htm
  • DOI: https://dx.doi.org/10.3748/wjg.v28.i21.2334