Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome: A multicenter retrospective study

doi:10.3748/wjg.v28.i21.2334

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

World J Gastroenterol. Jun 7, 2022; 28(21): 2334-2349
Published online Jun 7, 2022. doi: 10.3748/wjg.v28.i21.2334

Table 2 Sociodemographic and symptomatic characteristics of the study participants

	Total	Centers
	Total	Germany	Sweden	United States	United Kingdom	Ireland
n	100.0 (623)	45.1 (281)	18.3 (114)	19.6 (122)	12.4 (77)	4.7 (29)
Age	41.7 ± 16.1 (18, 91)	40.7 ± 16.4 (18, 88)	33.7 ± 11.8 (18, 60)	54.9 ± 14.6 (25, 91)	40.8 ± 11.6 (18, 70)	30.3 ± 8.6 (19, 51)
Sex
Female	69.5 (433)	63.3 (178)	69.3 (79)	77.9 (95)	72.7 (56)	86.2 (25)
IBS subtypes
IBS-C	14.1 (87)	8.9 (25)	12.3 (14)	36.7 (44)	0	13.8 (4)
IBS-D	41.7 (258)	43.4 (122)	19.6 (22)	28.3 (34)	100.0 (77)	10.3 (3)
IBS-M	42.5 (263)	45.6 (128)	67.0 (75)	31.7 (38)	0	75.9 (22)
IBS-U¹	1.8 (11)	2.1 (6)	0.9 (1)	3.3 (4)	0	0
Depressive symptoms	-	9.4 ± 5.9²	5.2 ± 3.5⁴	13.2 ± 9.6⁵	5.9 ± 4.0⁴	4.3 ± 3.2⁴
Anxiety symptoms	-	7.7 ± 4.8³	8.3 ± 4.5⁴	14.6 ± 9.7⁶	9.6 ± 4.6⁴	7.8 ± 4.5⁴
Symptom severity	-	280.3 ± 90.7⁷	297.3 ± 100.5⁷	43.2 ± 16.2⁸	-	-
Somatization symptoms⁹	14.8±6.3	16.2 ± 7.3	13.3 ± 4.7	13.8 ± 5.0	-	-

Sample size, sex, IBS subtypes, and severity of depressive and anxiety symptoms are presented as % (n). Age is presented as mean ± SD (range). Scores of depressive and anxiety symptoms are presented as mean ± SD.

¹Was not included in the later analysis because of the small sample size.

²Evaluated by the nine-item depression module from the Patient Health Questionnaire.

³Evaluated by the brief measurement for generalized anxiety disorder.

⁴Evaluated by Hospital Anxiety and Depression Scale.

⁵Evaluated by Beck Depression Inventory.

⁶Evaluated by Beck Anxiety Inventory.

⁷Evaluated by irritable bowel syndrome (IBS) symptom severity scale.

⁸Evaluated by the gastrointestinal symptom rating scale for IBS.

⁹Evaluated by the somatization module for the Patient Health Questionnaire.

IBS: Irritable bowel syndrome; IBS-C: Constipation-predominant IBS; IBS-D: Diarrhea-predominant IBS; IBS-M: IBS with mixed bowel habits; IBS-U: Unclassified IBS.

Citation: Berens S, Dong Y, Fritz N, Walstab J, D'Amato M, Zheng T, Wahl V, Boekstegers F, Bermejo JL, Martinez C, Schmitteckert S, Clevers E, Engel F, Gauss A, Herzog W, Spiller R, Goebel-Stengel M, Mönnikes H, Andresen V, Thomas F, Keller J, Pehl C, Stein-Thöringer C, Clarke G, Dinan TG, Quigley EM, Sayuk G, Simrén M, Tesarz J, Rappold G, van Oudenhove L, Schaefert R, Niesler B. Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome: A multicenter retrospective study. World J Gastroenterol 2022; 28(21): 2334-2349
URL: https://www.wjgnet.com/1007-9327/full/v28/i21/2334.htm
DOI: https://dx.doi.org/10.3748/wjg.v28.i21.2334