Advances in medical treatment for pancreatic neuroendocrine neoplasms

doi:10.3748/wjg.v28.i20.2163

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May 28, 2022 (publication date) through Dec 23, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 28, 2022; 28(20): 2163-2175
Published online May 28, 2022. doi: 10.3748/wjg.v28.i20.2163

Table 1 Ongoing clinical trials of immune checkpoint inhibitors in combination with other therapies for the treatment of neuroendocrine neoplasms

Drugs	Population	n	Phase	Primary outcomes	NCT number
Surufatinib + toripalimab vs FOLFIRI	NEC	194	III	OS	NCT05015621
Penpulimab + anlotinib	NET	150	II	ORR	NCT04207463
Pembrolizumab + liver-directed/PRRT	NET	32		ORR	NCT03457948
Nivolumab + chemotherapy	NEN G3	38	II	OS	NCT03980925
Toripalimab + FOLFSIM vs EP/EC	Advanced NEC	336	II/III	OS	NCT03992911
Nivolumab + ipilimumab + cabozantinib	PD-NET	30	II	ORR	NCT04079712
Pembrolizumab + lanreotide depot	GEP-NET	22	Ib/II	ORR	NCT03043664

FOLFIRI: Folinic acid, fluorouracil and irinotecan regimen; FOLFSIM: Simmtecan and 5-FU/LV regimen; EP: Etoposide and cisplatin regimen; EC: Etoposide and carboplatin regimen; PD-NET: Poorly differentiated neuroendocrine tumor; ORR: Objective response rate; OS: Overall survival.

Citation: Li YL, Cheng ZX, Yu FH, Tian C, Tan HY. Advances in medical treatment for pancreatic neuroendocrine neoplasms. World J Gastroenterol 2022; 28(20): 2163-2175
URL: https://www.wjgnet.com/1007-9327/full/v28/i20/2163.htm
DOI: https://dx.doi.org/10.3748/wjg.v28.i20.2163