Identification of functional tumor necrosis factor-alpha promoter variants associated with Helicobacter pylori infection in the Sudanese population: Computational approach

Table 8 Allele and genotype frequencies of tumor necrosis factor-alpha-1030 polymorphism among Helicobacter pylori-infected and uninfected subjects and their contributions to Helicobacter pylori infection, n (%)

		H. pylori (+ve), n = 61	H. pylori (-ve), n = 61	P value	OR (95%CI)
Allele frequency
	TNF-A-1030-T	88 (72.13)	98 (80.33)	0.176	0.63 (0.349-1.151)
	TNF-A-1030-C	34 (27.87)	24 (19.67)
Genotype frequency
	T/T	32 (52.46)	43 (70.49)	-	1 (reference)
	T/C	24 (39.34)	12 (19.67)	0.020a	2.69 (1.17-6.17)
	C/C	5 (8.20)	6 (9.84)	0.862	1.12 (0.31-3.99)

^aP value < 0.05 statistically significant difference. OR: Odds ratio; 95%CI: 95% confidence interval; H. pylori: Helicobacter pylori; +ve: Positive; -ve: Negative; TNF-A: Tumor necrosis factor-alpha.