Identification of functional tumor necrosis factor-alpha promoter variants associated with Helicobacter pylori infection in the Sudanese population: Computational approach

Table 6 Overview of conserved transcription factor binding sites predicted by multiple-sequence local alignment and visualization

Transcription Factor	Binding sequence	Position1		Conserved SNPs
		Start	End
V$CETS168_Q6	gCTTCCTC	-115	-108
V$ETS_Q6	gcTTCCtc	-115	-108
V$SP1_Q4_01	ttccCCGCCCtcc	-51	-39	rs765073823 [-48]rs537401710 [-47]
V$SP1_Q6_01	tcCCCGCCCt	-50	-41	rs765073823 [-48]rs537401710 [-47]
V$SP1_Q2_01	cCCCGCCCtc	-49	-40	rs765073823 [-48]rs537401710 [-47]

¹All positions are relative to the tumor necrosis factor-alpha mRNA cap site. Multiple-sequence local alignment and visualization (https://mulan.dcode.org/) to be conserved (100%) between human, chimpanzee, rhesus monkey, cow, and domesticated dog at the (-146 to +10) region. The crucial transcription factor for tumor necrosis factor transcription, nuclear factor, was not included.