Copyright
©The Author(s) 2022.
World J Gastroenterol. Jan 14, 2022; 28(2): 216-229
Published online Jan 14, 2022. doi: 10.3748/wjg.v28.i2.216
Published online Jan 14, 2022. doi: 10.3748/wjg.v28.i2.216
Table 3 Overview of the diagnostic parameters for hepatocellular carcinoma
| Diagnostic parameter (cut off) | Remark | AUROC |
| AFP (> 20 ng/mL) | Sensitivity: 40%–65% | 0.54–0.80 |
| Specificity: 76%–96% | ||
| AFP-L3 (> 15%) | Sensitivity: 45%–90% | 0.74–0.84 |
| Specificity: 95% | ||
| AFP-L3 + AFP-P4 + P5 (> 15% for both biomarkers) | Sensitivity: 55.3%–61% | 0.76 |
| Specificity: 82.3%–93.9% | ||
| AFP, AFP-L3 and DCP (3-25 ng/mL, 1%-10%, 0.48 ng/mL or 40 mAu/mL) | Sensitivity: 81%–93% | 0.88–0.93 |
| Specificity: 69%-87% | ||
| AFP and GP73 | Sensitivity: 75%-91% | 0.91–0.95 |
| Specificity: 81%-97% |
- Citation: Hanif H, Ali MJ, Susheela AT, Khan IW, Luna-Cuadros MA, Khan MM, Lau DTY. Update on the applications and limitations of alpha-fetoprotein for hepatocellular carcinoma. World J Gastroenterol 2022; 28(2): 216-229
- URL: https://www.wjgnet.com/1007-9327/full/v28/i2/216.htm
- DOI: https://dx.doi.org/10.3748/wjg.v28.i2.216