Fusobacterium nucleatum promotes colon cancer progression by changing the mucosal microbiota and colon transcriptome in a mouse model

Figure 1 Effect of F. nucleatum infection on colon carcinogenesis in the azoxymethane/dextran sulfate sodium-induced model. A: Experimental design illustrating the F. nucleatum infection strategy combined with azoxymethane/dextran sulfate sodium salt treatment; B: The body weight and survival curve of the three groups during the experiment was evaluated with two-way ANOVA; C: The colon lengths of the three groups were compared using a t-test; D: The numbers of tumors in the colon of the three groups were compared using a t-test; E: Hematoxylin-eosin staining and immunohistochemistry of E-cadherin-positive cells in the colon of the three groups. ^aP < 0.05; ^bP < 0.01. NS: No signification; AOM: Azoxymethane; DSS: Dextran sulfate sodium salt.