Clinical utility of two-dimensional shear-wave elastography in monitoring disease course in autoimmune hepatitis-primary biliary cholangitis overlap syndrome

Table 3 Diagnostic accuracy of two-dimensional shear-wave elastography for diagnosing liver fibrosis

	Cutoff	AUC (95%CI)	Sensitivity	Specificity	PPV	NPV	Accuracy
Significant fibrosis (≥ S2)
LS, kPa	12.1	0.91 (0.85-0.96)	67.5%	96.0%	98.8%	37.5%	72.3%
Rule out	7.9		95.1%	60.0%	92.1%	71.3%	89.2%
Rule in	12.1		67.5%	96.0%	98.8%	37.5%	72.3%
Severe fibrosis (≥ S3)
LS, kPa	15.0	0.97 (0.94-0.99)	85.3%	95.9%	95.5%	86.4%	90.5%
Rule out	11.9		94.7%	75.3%	79.8%	93.3%	85.1%
Rule in	15.0		85.3%	95.9%	95.5%	86.4%	90.5%
Cirrhosis (S4)
LS, kPa	15.1	0.96 (0.92-0.99)	90.3%	91.9%	88.9%	92.9%	91.2%
Rule out	13.9		95.2%	84.9%	82.0%	96.1%	89.2%
Rule in	19.4		58.1%	95.3%	89.9%	75.9%	79.7%

AUC: Area under the receiver operating characteristic curve; LS: Liver stiffness; PPV: Positive predictive value; NPV: Negative predictive value.