Incidental gallbladder cancer diagnosis confers survival advantage irrespective of tumour stage and characteristics

Table 5 Cox proportional hazard analysis for disease free survival

Variable	P value	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)
	Univariable analysis		Multivariable analysis		Multivariable analysis (excluding timing of diagnosis variable)
Age	0.275	1.02 (0.98-1.06)	-	-	-	-
Gender	0.732	0.85 (0.34-2.13)	-	-	-	-
Race	0.997	1.13 (0.15-8.51)	-	-	-	-
BMI	0.782	0.99 (0.91-1.07)	-	-	-	-
ASA score	0.817	0.91 (0.42-1.98)	-	-	-	-
CCI score	0.842	0.98 (0.76-1.26)	-	-	-	-
T stage	0.021	2.06 (1.12-3.82)	0.504	1.26 (0.64-2.47)	0.21	1.53 (0.79-2.97)
N stage	0.001	4.08 (1.83-9.08)	0.006	3.18 (1.39-7.26)	0.008	3.08 (1.35-7.06)
R status	< 0.001	11.05 (3.31-36.94)	0.006	5.76 (1.67-19.88)	0.002	6.95 (1.98-24.34)
Post-operative complications	0.404	0.63 (0.22-1.85)	-	-	-	-
Non-incidental diagnosis	0.011	2.78 (1.26-6.12)	0.09	2.13 (0.89-5.09)	Not included in analysis	Not included in analysis
Degree of differentiation	0.211	0.65 (0.33-1.28)	-	-	-	-
Adjuvant chemotherapy	0.457	1.42 (0.56-3.58)	-	-	-	-

ASA: American Society of Anesthesiology; CCI: Charlson Comorbidity Index; BMI: Body mass index.