Incidental gallbladder cancer diagnosis confers survival advantage irrespective of tumour stage and characteristics

Table 4 Cox proportional hazard analysis for overall survival

Variable	P value	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)
	Univariable analysis		Multivariable analysis		Multivariable analysis (excluding timing of diagnosis variable)
Age	0.011	1.04 (1.01-1.07)	0.453	1.02 (0.97-1.08)	0.153	1.04 (0.99-1.10)
Gender	0.96	1.01 (0.71-1.44)	-	-	-	-
Race	0.853	1.05 (0.61-1.81)	-	-	-	-
BMI	0.601	0.983 (0.92-1.05)	-	-	-	-
ASA score	0.024	1.96 (1.09-3.52)	0.121	2.26 (0.81-6.31)	0.061	2.53 (0.96-6.66)
CCI score	0.064	1.19 (0.99-1.42)	0.66	0.91 (0.58-1.41)	0.269	0.78 (0.50-1.21)
T stage	< 0.001	2.73 (1.72-4.34)	0.913	1.04 (0.56-1.90)	0.088	1.62 (0.93-2.81)
N stage	< 0.001	5.65 (2.84-11.25)	< 0.001	3.07 (1.72-5.46)	0.001	3.59 (1.72-7.49)
R status	< 0.001	7.35 (3.38-15.95)	< 0.001	5.26 (2.10-13.13)	0.012	3.00 (1.27-7.07)
Post-operative complications	0.885	1.05 (0.53-2.09)	-	-	-	-
Non-incidental diagnosis	0.004	2.41 (1.32-4.38)	0.026	2.25 (1.10-4.58)	Not included in analysis	Not included in analysis
Degree of differentiation	0.443	1.40 (0.61-3.21)	-	-	-	-
Adjuvant chemotherapy	0.87	1.07 (0.47-2.44)	-	-	-	-

ASA: American Society of Anesthesiology; CCI: Charlson Comorbidity Index; BMI: Body mass index.