Gut homeostasis, injury, and healing: New therapeutic targets

Figure 5 Current and promising new therapeutic approaches to gastrointestinal mucosal healing. Green represents currently available drugs. Red represents promising new therapeutic approaches that increase mucosal defense. Blue represents promising new therapeutic approaches that promote mucosal repair. Purple represents promising new therapeutic approaches that stimulate both mucosal defense and repair. PPIs: Proton pump inhibitors; H2-antagonists: Histamine-2 receptor antagonists; RX77368: The thyrotropin-releasing hormone analog; SCFAs: Short-chain fatty acids; FAK: Focal adhesion kinase; MFG-E8: Milk fat globule-epidermal growth factor 8; Flii: Flightless I.