Epidemiological characteristics of Asian children with inflammatory bowel disease at diagnosis: Insights from an Asian-Pacific multi-centre registry network

Table 4 Disease characteristics of Crohn’s disease and ulcerative colitis

Disease characteristics	N	SA	P value (SA vs non-SA)
CD	n = 174	n = 35 (20.1)
Disease severity based on PCDAI score (n, column %)1
Inactive (≤ 10)	17 (12.3)	4 (14.3)	NS
Mild (11-30)	46 (33.3)	9 (32.1)
Moderate-severe (> 30)	75 (54.3)	15 (53.6)
Disease location (n, column %)
L1 (distal 1/3 ileum +/- limited caecal disease)	28 (18.7)	4 (12.5)	0.505 (SA)
L2 (colonic)	54 (36.0)	10 (31.3)
L3 (ileocolonic)	62 (41.3)	16 (50.0)
Isolated L4 disease	6 (4.0)	2 (6.3)
L4a	59 (40.7)	13 (39.4)	0.973 (SA)
L4b	12 (8.3)	3 (9.1)
No L4 disease	74 (51.0)	17 (51.3)
Disease behaviour (n, %)
B1 (inflammatory)	136 (90.7)	31 (93.9)	0.858 (SA)
B2 (stricturing)	5 (3.3)	1 (3.0)
B3 (penetrating)	8 (5.3)	1 (3.0)
B2/B3	1 (0.7)	0 (0.0)
Perianal involvement (n, %)
Perianal symptoms at presentation	23 (13.2)	10 (28.6)	0.003 (SA)
Any form of perianal manifestation (clinical exam or imaging)	53 (30.5)	18 (51.4)	0.003 (SA)
UC	n = 119	n = 33 (27.7)
Disease severity based on PUCAI score (n, column %)2
Inactive (< 10)	7 (8.3)	0 (0.0)	0.353 (SA)
Mild (10-34)	36 (42.9)	11 (47.8)
Moderate (35-64)	28 (33.3)	9 (39.1)
Severe (≥ 65)	13 (15.5)	3 (13.0)
Disease location (n, column %)
E1 (proctitis)	8 (7.5)	2 (6.9)	0.353 (SA)
E2 (left sided)	16 (15.1)	5 (17.2)
E3 (extensive)	5 (4.7)	5 (17.2)
E4 (pancolitis)	77 (72.6)	17 (58.6)
Disease severity (n, column %)
S0 (never severe)	79 (78.2)	20 (74.1)	0.542 (SA)
S1 (ever severe)	22 (21.8)	7 (25.9)

¹Disease activity scores available only for 138/174 Crohn’s disease patients.

²Disease severity scores available for 84/119 Ulcerative colitis patients.

CD: Crohn’s disease; PCDAI: Pediatric Crohn’s Disease Activity Index; PUCAI: Pediatric Ulcerative Colitis Activity Index; SA: South Asian; UC: Ulcerative colitis.