Establishing a rabbit model of perianal fistulizing Crohn’s disease

Figure 3 The rabbits in groups A and B underwent three consecutive endoscopic biopsies, and samples were stained with haematoxylin-eosin. A: Group A exhibited mild to moderate inflammation on day 7, manifested by fewer crypts, marked mucosal oedema, and minimal inflammatory cell infiltration; Group A exhibited fibrosis, hyperaemia, and moderate inflammatory cell infiltration on day 14, and severe inflammatory mucosal ulceration on day 21; B: On the 7^th day, there was a higher number of shallow crypts, less oedema and less inflammatory cell infiltration in group B. On the 14^th day, there was severe oedema, decreased crypts and less inflammatory cell infiltration in the mucosa, and on the 21^st day, there was moderate fibrosis and oedema, mild inflammatory cell infiltration and a complete crypt structure (magnification ×100).