Validation model of fibrosis-8 index score to predict significant fibrosis among patients with nonalcoholic fatty liver disease

Table 3 Performance of fibrosis-8, fibrosis-4, and nonalcoholic fatty liver disease fibrosis score for predicting significant fibrosis (F ≥ 2) in the Asian population (n = 511)

	FIB-8 score	FIB-4 score	NFS
AUC for predicting ≥ F2 fibrosis	0.77a,b	0.74	0.68
95% confidence interval	0.73-0.82	0.70-0.79	0.63-0.73
Low and high cutoffs for ≥ F2 fibrosis	0.88 and 1.77	0.81 and 1.81 (17)	-2.45 and 0.03 (17)
Sensitivity (according to the low cutoff)	92.36%	80.25%	80.89%
Specificity (according to the high cutoff)	67.51%	93.50%	93.20%
Proportion of patients in low/indeterminate/high group	18.8/35.4/45.8%	38.2/47.1/14.7%	31.9/58.1/10%

^aP = 0.001 compared with NFS.

^bP = 0.073 compared with FIB-4.

NAFLD: Nonalcoholic fatty liver disease; FIB-8: Fibrosis-8 score; FIB-4: Fibrosis-4 score; NFS: NAFLD fibrosis score; AUROC: Areas under the receiver operating characteristic curves.