Validation model of fibrosis-8 index score to predict significant fibrosis among patients with nonalcoholic fatty liver disease

Table 1 Details of the three noninvasive methods used in this study

Index	Number of parameters and variables	Formula	Ref.
FIB-8 index	8; age, AST, ALT, platelets, BMI, albumin/globulin, GGT, diabetes	FIB4 + 0.025 × BMI (kg/m2) - 0.702 × (albumin/globulin ratio) + 0.004 × GGT (U/L) + 0.858 × diabetes (yes = 1, no = 0)1	Sripongpun et al[11], 2019
FIB-4 index	4; age, AST, ALT, platelets	Age (years) × AST (U/L)/[platelet count (109/L) × √ALT (U/L)]	Sterling et al[15], 2006
NFS	6; age, BMI, diabetes, AST/ALT, platelets, albumin	-1.675 + 0.037 × age (years) + 0.094 × BMI (kg/m2) + 1.13 × impaired fasting glucose/diabetes (yes = 1, no = 0) + 0.99 × AST/ALT ratio - 0.013 × platelet count (× 109/L) - 0.66 × albumin (g/dL)	Angulo et al[16], 2007

¹The FIB-8 score in the abstract was calculated by 1.3 × FIB-4 + 0.03 × BMI - 0.93 × (albumin/globulin ratio) + 0.005 × GGT (U/L) + 1.1 × diabetes (yes = 1, no = 0), which is slightly different from the actual formula presented at the liver meeting congress (the score in the table). We have contacted the authors of the abstract and were informed that the actual formula to use is the one shown in the table.

NAFLD: Nonalcoholic fatty liver disease; FIB-8: Fibrosis-8 score; FIB-4: Fibrosis-4 score; NFS: NAFLD fibrosis score; AUROC: Areas under the receiver operating characteristic curves; GGT: Gamma-glutamyl transferase; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; BMI: Body mass index.