Reevaluation of the expanded indications in undifferentiated early gastric cancer for endoscopic submucosal dissection

Table 5 Logistic regression analysis for the risk of Lymph node metastasis

Variable	OR	95%CI	P value
Depth of invasion
LP	1
MM	0.44	0.09-2.15	0.312
Diagnostic category according to % of SRCs
Non-mixed (SRC and PD)	1
Mixed (PD with SRC component)	6.37	0.79-51.6	0.083
Background stomach
CG	1
CAG	2.86	0.74-11.1	0.129
Presence of H. pylori
Absent (0)	1
Present (≥ 1+)	2.88	0.59–13.9	0.190
TIL abundance			0.409
< 10%	1
10%-20%	0.65	0.19-2.17	0.484
≥ 20%	0.24	0.03-2.13	0.199
Fibrosis score	0.34	0.05-2.49	0.285
Blurring of MM
Non-diffuse (absent/focal)	1
Diffuse	0.12	0.02-0.95	0.045

LNM: Lymph node metastasis; OR: Odds ratio; LP: Lamina propria; MM: Muscularis mucosa; SRC: Signet ring cell; SRCC: Signet ring cell carcinoma; PD: Poorly differentiated carcinoma encompassing adenocarcinoma and non-signet ring cell type of poorly cohesive carcinoma; CG: Chronic gastritis; CAG: Chronic active gastritis; TIL: Tumor-infiltrating lymphocytes; H. pylori: Helicobacter pylori.