Reevaluation of the expanded indications in undifferentiated early gastric cancer for endoscopic submucosal dissection

Table 3 Histologic features of the tumors and background stomach according to the presence of lymph node metastasis

Variables	LNM- (n = 73)	LNM+ (n = 14)	P value
Depth of invasion			0.503
LP	53 (72.6)	12 (85.7)
MM	20 (27.4)	2 (14.3)
Size, cm	1.5 (1.2-1.7)	1.5 (1.3-1.8)	0.642
% of SRCs			0.157
< 10%	17 (23.3)	0 (0)
≥ 10% and < 50%	35 (47.9)	10 (71.4)
≥ 50% and < 90%	14 (19.2)	3 (21.4)
≥ 90%	7 (9.6)	1 (7.1)
Diagnostic category according to the proportion of SRCs			0.059
Non-mixed (SRCC and PD)	24 (32.9)	1 (7.1)
Mixed (PD with SRC component)	49 (67.1)	13 (92.9)
Background stomach			0.278
Mild CG	8 (11.0)	0 (0)
Moderate CG or IM	24 (32.9)	3 (21.4)
CAG	22 (30.1)	4 (28.6)
CAG with visible H. pylori	19 (26.0)	7 (50.0)
H. pylori abundance, n/total n			0.263
0	23/71 (32.4)	2/14 (14.3)
1+	14/71 (19.7)	3/14 (21.4)
2+	14/71 (19.7)	6/14 (42.9)
3+	20/71 (28.2)	3/14 (21.4)
TP53 expression, n/total			> 0.999
Loss (0)	3/70 (4.3)	0/14 (0)
Wildtype pattern (1+/2+)	63/70 (90.0)	13/14 (92.9)
Overexpression (3+)	4/70 (5.7)	1/14 (7.1)

LNM: Lymph node metastasis; IQR: Interquartile range; LP: Lamina propria; MM: Muscularis mucosa; SRC: Signet ring cell; SRCC: Signet ring cell carcinoma; PD: Poorly differentiated carcinoma encompassing adenocarcinoma and non-signet ring cell type of poorly cohesive carcinoma; CG: Chronic gastritis; IM: Intestinal metaplasia; CAG: Chronic active gastritis; H. pylori: Helicobacter pylori.