Novel approaches in search for biomarkers of cholangiocarcinoma

doi:10.3748/wjg.v28.i15.1508

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Apr 21, 2022 (publication date) through Feb 3, 2025

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World Journal of Gastroenterology

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World J Gastroenterol. Apr 21, 2022; 28(15): 1508-1525
Published online Apr 21, 2022. doi: 10.3748/wjg.v28.i15.1508

Table 2 Proteins associated with favorable cholangiocarcinoma diagnostic potential

Protein	Comparison	SEN (%)	SPE (%)	AUC	Ref.
	Tissue
CYFRA 21-1	iCCA (n = 217) vs HC (n = 514) meta-analysis	81.0	86.0	0.904	[58]
DKK1	iCCA (n = 37) vs HC (n = 50)	75.7	100.0	0.872	[52]
DKK1 + CA19-9	iCCA(n = 79) vs HC (n = 160)	74.7	56.3	0.793	[60]
IL-6	CCA (n = 26), HCC (n = 26) and HC (n = 23)	73.0	92.0	0.875	[53]
MMP-7	CCA (n = 44) vs benign BTD (n = 36)	76.3	46.8	0.730	[56]
MMP-7	CCA (n = 59) vs benign BTD (n = 128)	75.0	78.0	0.840	[57]
MUC5AC	CCA (n = 49), benign BTD (n = 23), HC (n = 16)	71.0	94.7	0.909	[55]
OPN	CCA (n = 107) vs HC (n = 55)	87.5	100.0	0.964	[50]
S100A6	CCA (n = 112) vs HC (n = 42)	86.2	90.9	0.909	[51]
SSP411	CCA (n = 30), benign BTD (n = 13) and HC (n = 23)	90.0	83.3	0.913	[54]
TGF-β1	CCA (n = 45), other disease conditions related inflammation (n = 25) and HC (n = 45)	71.1	68.9	0.668	[78]
TSP-2 + CA19-9	dCCA (n = 51), pancreatic ductal adenocarcinoma (n = 52), benign pancreatic diseases (n = 27) and HC (n = 52)	79.0	96.0	0.920	[61]
uPAR	CCA (n = 118), and HC (n = 76)	95.3	89.7	0.969	[59]
Biomarker panel: S100A9, MUC5AC, TGF-β1, Ang-2, and CA19-9	CCA (n = 40), non-CCA (n = 40) and HC (n = 40)	95.0	90.0	0.975	[62]

AUC: Area under the curve; BTD: Biliary tract disease; CCA: Cholangiocarcinoma; dCCA: Distal CCA; HC: Healthy controls; HCC: Hepatocellular carcinoma; iCCA: Intrahepatic cholangiocarcinoma; SEN: Sensitivity; SPE: Specificity; CYFRA 21-1: Cytokeratin 19 fragment; DKK1: Dickkopf 1; IL-6: Interleukin 6; MMP-7: Metalloproteinase 7; MUC5AC: Mucin 5AC; OPN: Osteopontin; S100A6: S100 calcium binding protein A6; SSP411: Spermatogenesis-associated protein 20; TGF-β1: Transforming growth factor-β1; TSP-2: Thrombospondin-2; uPAR: Urokinase-type plasminogen activator receptor; S100A9: S100 calcium binding protein A9; Ang-2: Angiopoietin-2.

Citation: Mocan LP, Ilieș M, Melincovici CS, Spârchez M, Crăciun R, Nenu I, Horhat A, Tefas C, Spârchez Z, Iuga CA, Mocan T, Mihu CM. Novel approaches in search for biomarkers of cholangiocarcinoma. World J Gastroenterol 2022; 28(15): 1508-1525
URL: https://www.wjgnet.com/1007-9327/full/v28/i15/1508.htm
DOI: https://dx.doi.org/10.3748/wjg.v28.i15.1508