Generic and disease-specific health-related quality of life in patients with Hirschsprung disease: A systematic review and meta-analysis

Table 3 Summary estimates Hirschsprung disease / Anorectal malformation Quality of Life scores

Summary estimates HAQL scores	Aggregated HAQL domain scores[21,61,70]1	Hanneman et al[4], 2001
Domain	Mean (SD)	Mean rank
Laxative diet	88.41 (19.63)	64.67
Constipating diet	91.67 (17.39)	63.77
Diarrhea	73.32 (26.86)	61.22
Constipation	83.33 (36.51)	64.75
Urinary continence	94.82 (13.57)	65.72
Fecal incontinence	78.70 (24.47)	68.58
Social functioning	93.77 (15.40)	65.33
Emotional functioning	84.42 (19.92)	65.11
Body image	84.70 (20.08)	65.48
Physical symptoms	69.33 (19.09)	58.52

¹The average of mean scores was calculated across domain scores of each studies and aggregated into a weighted mean (SD). HAQL: Hirschsprung disease/anorectal malformation quality of life.