Emerging role of colorectal mucus in gastroenterology diagnostics

doi:10.3748/wjg.v28.i12.1220

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Mar 28, 2022; 28(12): 1220-1225
Published online Mar 28, 2022. doi: 10.3748/wjg.v28.i12.1220

Table 1 Comparison of tested colorectal mucus biomarker performance for colorectal cancer detection versus groups of asymptomatic control subject and patients with abdominal symptoms (based upon receiver operating characteristic curve analysis)

Biomarker	Optimal cut-off level	Sensitivity (%)	AUC vs Sympt. Pat-s (95%CI)	Specificity vs Sympt. Pat-s (%)	AUC vs Control (95%CI)	Specificity vs Control (%)	Median biomarker level (CRC)	Median biomarker level (Sympt. Pat-s)	Median biomarker level (Control)
Haemoglobin	109.27 ng/mL	80.00	0.85 (0.77-0.93)	88.55	0.92 (0.85-0.99)	94.29	1708.74 ng/mL^a^,^b	0.00 ng/mL^a^,^c	0.00 ng/mL^b^,^c
CRP	8.90 ng/mL	72.50	0.77 (0.68-0.87)	75.81	0.84 (0.75-0.93)	80.00	22.09 ng/mL^d^,^e	1.41 ng/mL^d	0.00 ng/mL^e
TIMP1	3.25 ng/mL	67.50	0.73 (0.63-0.84)	75.81	0.83 (0.74-0.92)	85.71	8.26 ng/mL^f^,^g	1.42 ng/mL^f^,^h	0.71 ng/mL^g^,^h
M2-PK	9.00 U/mL	62.50	0.71 (0.60-0.81)	77.42	0.83 (0.74-0.92)	91.43	11.98 U/mLⁱ^,^j	2.97 U/mLⁱ^,^k	0.57 U/mL^j^,^k
MMP9	10.38 ng/mL	65.00	0.70 (0.60-0.80)	64.52	0.86 (0.78-0.95)	82.86	20.93 ng/mL^l^,^m	6.37 ng/mL^l^,ⁿ	0.44 ng/mL^m^,ⁿ
PADI4	1.16 ng/mL	67.50	0.64 (0.54-0.75)	62.90	0.88 (0.81-0.96)	94.29	1.51 ng/mL^o^,^p	0.88 ng/mL^o^,^q	0.00 ng/mL^p^,^q
EGFR	305.52 pg/mL	60.00	0.60 (0.48-0.71)	58.06	0.80 (0.70-0.90)	88.57	342.72 pg/mL^r	187.01 pg/mL^s	67.72 pg/mL^r^,^s
Calprotectin	3.38 μg/mL	57.50	0.58 (0.47-0.70)	56.45	0.75 (0.64-0.86)	80.00	4.01 μg/mL^t	2.94 μg/mL^u	0.59 μg/mL^t^,^u
EDN	12.83 ng/mL	45.00	0.52 (0.40-0.64)	62.90	0.74 (0.62-0.85)	88.57	8.04 ng/mL^v	10.10 ng/mL^w	2.85 ng/mL^v^,^w

P value for CM biomarker level comparisons between study groups.

^{a,b,d,e,g,j,m,p,q,r}P < 0.00001.

^cP = 0.01878.

^fP = 0.00008.

^hP = 0.0264.

ⁱP = 0.00040.

^kP = 0.01352.

^lP = 0.00078.

ⁿP = 0.00288.

^oP = 0.01428.

^s,tP = 0.00020.

^uP = 0.00042.

^vP = 0.00044.

^wP = 0.00064.

CRP: C-reactive protein; TIMP1: Tissue inhibitor of metalloproteinase 1; M2-PK: M2-pyruvate kinase; MMP9: Matrix metalloproteinase 9; PADI4: Peptidyl arginine deiminase-4; EGFR: Epidermal growth factor receptor; EDN: Eosinophil-derived neurotoxin; AUC: Area under the curve.

Citation: Nooredinvand HA, Poullis A. Emerging role of colorectal mucus in gastroenterology diagnostics. World J Gastroenterol 2022; 28(12): 1220-1225
URL: https://www.wjgnet.com/1007-9327/full/v28/i12/1220.htm
DOI: https://dx.doi.org/10.3748/wjg.v28.i12.1220