Assessment of pathogens and risk factors associated with bloodstream infection in the year after pediatric liver transplantation

Table 3 Multivariate analyses of risk factors for blood stream infection after liver transplantation

Variables	Non-BSI, n = 272		BSI, n = 106			Multivariate analysis
	Median or n	(IQR) or (%)	Median or n	(IQR) or (%)	P value1	ORs	95%CI	P value
Age	1.83	(0.86-6.0)	1.17	(0.75-3.08)	0.005	2.1	(1.18-3.77)	0.011
Sex, male	124	(45.6)	52	(49)	0.544
Height, z-score	-0.66	(-1.60-0.34)	-1.23	(-2.17-0.0)	0.005	1.1	(0.54-2.37)	0.722
Weight, z-score	-0.07	(-1.04-0.71)	-0.53	(-1.7-0.4)	0.002	1.2	(0.70-2.25)	0.438
Growth failure	52	(19)	42	(40)	< 0.001	2.1	(1.01-4.47)	0.045
Diagnosis: Biliary atresia	134	(49)	66	(62)	0.023	1.2	(0.66-2.15)	0.546
Ventilator	14	(5.1)	11	(10)	0.066
Renal replacement	11	(4.0)	8	(7.5)	0.161
Liver support system	10	(3.7)	10	(9.4)	0.025	4.2	(1.45-12.09)	0.008
PELD	16.2	(6.40-23.7)	15.5	(10.6-24.3)	0.209
MELD	27.1	(11.3-32.3)	29	(27.8-29.7)	0.746
LT, DDLT	71	(26)	20	(19)	0.139
ABO mismatch	8	(2.9)	3	(2.8)	0.954
Operation time, min	417	(357-536)	411	(350-507)	0.408
RBC transfusion, cc/kg	17.4	(7.6-29.5)	25.7	(9.8-42.1)	0.003	1.5	(0.87-2.50)	0.146
Post-LT hospital stay	36	(26-50)	41	(28-67)	0.002	2.3	(1.35-3.91)	0.002
Donor, male	128	(47)	44	(42)	0.33
Donor, body mass index	22.3	(20.3-24.4)	22.7	(21.1-24.5)	0.267
Reoperation	29	(11)	21	(20)	0.018	1.30	(0.64-2.61)	0.470
Hepatic artery complication	2	(0.7)	2	(2.0)	0.326
Hepatic vein complication	24	(8.8)	15	(14)	0.126
Portal vein complication	27	(9.9)	24	(23)	0.001	1.85	(0.95-3.59)	0.070
Bile duct complication	16	(5.9)	5	(4.7)	0.657
Cytomegalovirus infection	161	(59)	61	(58)	0.771
Epstein–Barr virus infection	187	(69)	72	(68)	0.839
Acute cellular rejection	127	(47)	59	(56)	0.117

¹Mann–Whitney U test, χ² test, or Fisher's exact test.

BSI: Blood stream infection; DDLT: Deceased donor liver transplantation; IQR: Interquartile range; MELD: Model for End-Stage Liver Disease; OR: Odds ration; PELD: Pediatric End-Stage Liver Disease; LT: Liver transplantation.