Dynamics of cytokines predicts risk of hepatocellular carcinoma among chronic hepatitis C patients after viral eradication

Figure 3 Multivariate Cox regression analysis of tumor necrosis factor-α associated with hepatocellular carcinoma in subgroups. Comparison of the cumulative probability of hepatocellular carcinoma development divided by Δtumor necrosis factor-α with a cutoff value of -5.7 pg/mL in patients with (A) hemoglobin A1c (HbA1c) < 7%, (B) age < 65 years old and (C) HbA1c < 7% and age < 65 years old. The P value was adjusted by age, sex, Fibrosis-4 index, and HbA1c. HR: Hazard ratio; CI: Confidence interval; HCC: Hepatocellular carcinoma; TNF-α: Tumor necrosis factor-α; HbA1c: Hemoglobin A1c.