Progressive liver injury and increased mortality risk in COVID-19 patients: A retrospective cohort study in China

Figure 2 Association between drugs and liver injury. A: Cumulative incidence of liver biochemical abnormality or injury and drugs used during the whole course; B: Cumulative incidence of acute liver injury and drugs used during the whole course; C: In-hospital incidence of acute liver injury and drugs used after admission; D: In-hospital worsening liver biochemistry and drugs used after admission. Univariate model refers to univariate binary logistic regression model. Multivariate model refers to multivariate binary logistic regression model adjusted by age, sex, comorbidities (defined as history of at least one disease out of hypertension, diabetes, cardiovascular disease, cerebrovascular disease, chronic renal disease, chronic respiratory disease, and chronic liver disease), in-hospital disease severity status, lymphocyte count, D-dimer, and serum ferritin. Antivirals included oseltamivir, arbidol, lopinavir/ritonavir, and some other uncommonly used antiviral drugs. OR: Odds ratio; CI: Confidence interval; ALI: Acute liver injury; LB: Liver biochemistry; LBAI: Liver biochemical abnormality or injury.