Abdominal paracentesis drainage attenuates intestinal inflammation in rats with severe acute pancreatitis by inhibiting the HMGB1-mediated TLR4 signaling pathway

Figure 1 Effects of abdominal paracentesis drainage on pancreatic histopathology and proinflammatory cytokines. A: Representative images of rat pancreatic tissue from different groups following hematoxylin and eosin staining (bar = 100 μm); B: Histology severity score of pancreas tissue; C: Amylase; D: Lipase; E: Tumor necrosis factor-α; F: Interleukin-6; G: High mobility group box 1. All data are presented as mean ± SD (n = 6). ^aP < 0.05 vs sham group; ^bP < 0.05 vs severe acute pancreatitis group. SAP: Severe acute pancreatitis; APD: Abdominal paracentesis drainage; TNF-α: Tumor necrosis factor-α; IL-6: Interleukin-6; PAAF: Pancreatitis-associated ascitic fluid; HMGB1: High mobility group box 1.